Update on the use of immunoglobulin in human disease: A review of evidence

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:139

Review

Perez, Elena E.¹  Orange, Jordan S.^2,3  Bonilla, Francisco^4,5  Chinen, Javier^2,3  Chinn, Ivan K.^2,3  Dorsey, Morna^6,7,8  El-Gamal, Yehia^9,10  Harville, Terry O.^11,12  Hossny, Elham^9,10  Mazer, Bruce^13,14  Nelson, Robert^15,16  Jordan, Stanley C.^17,18,19  Stiehm, Richard²⁰  Vo, Ashley A.²¹  Ballow, Mark²² 

[1] Allergy Associates Palm Beaches, North Palm Beach, FL USA

[2] Texas Childrens Hosp, Ctr Human Immunobiol, Sect Immunol Allergy & Rheumatol, Dept Pediat, Houston, TX 77030 USA

[3] Baylor Coll Med, Houston, TX 77030 USA

[4] Childrens Hosp Boston, Clin Immunol Program, Dept Pediat, Boston, MA USA

[5] Harvard Med Sch, Boston, MA USA

[6] Benioff Childrens Hosp, Dept Pediat Allergy Immunol, San Francisco, CA USA

[7] Benioff Childrens Hosp, BMT Div, San Francisco, CA USA

[8] Univ Calif San Francisco, San Francisco, CA 94143 USA

[9] Childrens Hosp, Dept Pediat, Pediat Allergy & Immunol Unit, Cairo, Egypt

[10] Ain Shams Univ, Cairo, Egypt

[11] Univ Arkansas, Dept Pathol, Little Rock, AR 72204 USA

[12] Univ Arkansas, Lab Serv & Pediat, Little Rock, AR 72204 USA

[13] Montreal Childrens Hosp, Dept Pediat Allergy & Immunol, Montreal, PQ, Canada

[14] McGill Univ, Montreal, PQ, Canada

[15] Indiana Univ Sch Med, Dept Med & Pediat, Div Hematol & Oncol & Stem Cell Transplantat, Riley Hosp, Indianapolis, IN 46202 USA

[16] IU Melvin & Bren Simon Canc Ctr, Indianapolis, IN USA

[17] Wayne State Univ, Childrens Hosp Michigan, Dept Pediat, Detroit, MI USA

[18] Univ Calif Los Angeles, David Geffen Sch Med, Nephrol & Transplant Immunol, Kidney Transplant Program, Los Angeles, CA 90095 USA

[19] Cedars Sinai Med Ctr, Los Angeles, CA 90048 USA

[20] Univ Calif Los Angeles, David Geffen Sch Med, Dept Pediat, Los Angeles, CA 90095 USA

[21] Cedars Sinai Med Ctr, Transplant Immunotherapy Program, Comprehens Transplant Ctr, Kidney Transplant Program, Los Angeles, CA 90048 USA

[22] Univ S Florida, Morsani Coll Med, Dept Pediat, Johns Hopkins All Childrens Hosp,Div Allergy & Im, St Petersburg, FL 33701 USA

关键词: Immune globulin;    immunoglobulin;    IVIG;    SCIG;    IGIV;    transfusion;    adverse events;    primary immunodeficiency;    immunomodulation;    immune modulating;    autoimmunity;   

DOI  :  10.1016/j.jaci.2016.09.023

来源: Elsevier

【 摘 要 】

Human immunoglobulin preparations for intravenous or subcutaneous administration are the cornerstone of treatment in patients with primary immunodeficiency diseases affecting the humoral immune system. Intravenous preparations have a number of important uses in the treatment of other diseases in humans as well, some for which acceptable treatment alternatives do not exist. We provide an update of the evidence-based guideline on immunoglobulin therapy, last published in 2006. Given the potential risks and inherent scarcity of human immunoglobulin, careful consideration of its indications and administration is warranted. (J Allergy Clin Immunol 2017; 139: S1-46.)

【 授权许可】

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