CLASSICAL PATHWAY COMPLEMENT ACTIVATION IN KAWASAKI SYNDROME

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:93

Article

关键词: KAWASAKI SYNDROME;    COMPLEMENT;    CYTOKINE;    C4D;    C3D;    MEMBRANE ATTACK COMPLEX;    BB;    IL-6;    CLASSICAL PATHWAY;   

DOI  :  10.1016/0091-6749(94)90362-X

来源: Elsevier

【 摘 要 】

In this study the complement breakdown products C3d, C4d, Bb and membrane attack complex were measured in plasma of patients with Kawasaki syndrome. The results suggested strong activation of the classical activation pathway. However, there was no significant decrease in hemolytic titer or in the concentrations of the intact proteins C3, C4, and B. The relationship between the serum concentrations of cytokines and complement components was examined; increased interleukin-6 concentration on the fifth day after the onset of fever was found to correlate well with the C3 and B concentrations in serum obtained 5 days later We conclude that complement activation occurred in Kawasaki syndrome via the classical pathway but that the inflammatory reaction was accompanied by increased production of complement components. As a result, there was increased formation of activation products without changes in the serum complement levels.

【 授权许可】

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