The microbiome in allergic disease: Current understanding and future opportunities-2017 PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:139

Article

Huang, Yvonne J.¹  Marsland, Benjamin J.²  Bunyavanich, Supinda^3,4,5  O'Mahony, Liam⁶  Leung, Donald Y. M.⁷  Muraro, Antonella⁸  Fleisher, Thomas A.⁹ 

[1] Univ Michigan, Dept Internal Med, Div Pulm & Crit Care, Ann Arbor, MI 48109 USA

[2] Univ Lausanne, Fac Biol & Med, Serv Pneumol, CH-1015 Lausanne, Switzerland

[3] Icahn Sch Med Mt Sinai, Dept Pediat, Div Allergy & Immunol, New York, NY 10029 USA

[4] Icahn Sch Med Mt Sinai, Dept Genet, New York, NY 10029 USA

[5] Icahn Sch Med Mt Sinai, Dept Genom Sci, New York, NY 10029 USA

[6] Univ Zurich, Swiss Inst Allergy & Asthma Res, Mol Immunol, Davos, Switzerland

[7] Natl Jewish Hlth, Div Allergy & Immunol, Dept Pediat, Denver, CO USA

[8] Padua Gen Univ Hosp, Dept Women & Child Hlth, Food Allergy Referral Ctr Veneto Reg, Padua, Italy

[9] NIH, Dept Lab Med, Ctr Clin, 10 Ctr Dr,MSC 1508, Bethesda, MD 20892 USA

关键词: Microbiome;    microbiota;    dysbiosis;    asthma;    atopic dermatitis;    food allergy;    systems biology;    probiotic;    prebiotic;   

DOI  :  10.1016/j.jaci.2017.02.007

来源: Elsevier

【 摘 要 】

PRACTALL is a joint initiative of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology to provide shared evidence-based recommendations on cutting-edge topics in the field of allergy and immunology. PRACTALL 2017 is focused on what has been established regarding the role of the microbiome in patients with asthma, atopic dermatitis, and food allergy. This is complemented by outlining important knowledge gaps regarding its role in allergic disease and delineating strategies necessary to fill these gaps. In addition, a review of progress in approaches used to manipulate the microbiome will be addressed, identifying what has and has not worked to serve as a baseline for future directions to intervene in allergic disease development, progression, or both.

【 授权许可】

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