Increased risk of serious pneumococcal disease in patients with asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:122

Article

Juhn, Young J.¹  Yawn, Barbara P.²  Yoo, Kwang H.³  McGree, Michaela E.⁴  Weaver, Amy L.⁴  Wollan, Peter² 

[1] Mayo Clin, Dept Pediat & Adolescent Med, Div Community Pediat & Adolescent Med, Rochester, MN 55905 USA

[2] Olmsted Med Ctr, Dept Res, Rochester, MN USA

[3] Konkuk Univ, Sch Med, Dept Internal Med, Seoul, South Korea

[4] Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA

关键词: asthma;    invasive pneumococcal disease;    epidemiology;    risk;    microbial infection;    pneumococcal pneumonia;    adults;    Rochester Epidemiology Project;   

DOI  :  10.1016/j.jaci.2008.07.029

来源: Elsevier

【 摘 要 】

Background: Individuals with asthma have been reported to be at increased risk of invasive pneumococcal disease (IPD). These findings need to be confirmed in a different population-based study setting. Objective: We assessed whether serious pneumococcal disease (SPD), defined as an IPD, pneumococcal pneumonia, or both, was associated with asthma status. Methods: This is a retrospective case-control study using criteria-based methods for ascertaining SPD, as well as asthma. Subjects were residents of Rochester, Minnesota, who had SPD between 1964 and 1983 (the primarily pre-pneumococcal vaccine era) and their age-and sex-matched control subjects using 1:2 matching. Potential cases and control subjects were identified by using the Rochester Epidemiology project database and confirmed by medical record reviews. All cases and control subjects were merged with the database comprising the entire pool of Rochester residents with and without asthma between 1964 and 1983. Results: A total of 3941 records of potential patients with SPD were reviewed, and we identified 174 cases of SPD (51% male subjects and 94% white subjects). SPD was associated with a history of asthma among all ages (odds ratio, 2.4; 95% CI, 0.96.6; P = .09) and among adults (odds ratio, 6.7; 95% CI, 1.627.3; P = .01), controlling for high-risk conditions for IPD and smoking exposure. The population-attributable risk percentage was 17% in the adult population. Conclusion: Adults with asthma might be at increased risk of SPD.

【 授权许可】

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