Mast cells within cellular networks

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:144

Article

Stassen, Michael^1,2  Hartmann, Ann-Kathrin^1,2  Delgado, Sharon Jimenez^3,4,5,6  Dehmel, Susann^3,4,5  Braun, Armin^3,4,5,6 

[1] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Immunol, Langenbeckstr 1, D-55131 Mainz, Germany

[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Res Ctr Immunotherapy FZI, Mainz, Germany

[3] Fraunhofer Inst Toxicol & Expt Med, Hannover, Germany

[4] German Ctr Lung Res DZL, Biomed Res Endstage & Obstruct Lung Dis Breath Re, Hannover, Germany

[5] Cluster Excellence Regenerat Biol Reconstruct The, Hannover, Germany

[6] Hannover Med Sch, Inst Immunol, Hannover, Germany

关键词: Mast cells;    neutrophils;    eosinophils;    T cells;    asthma;    murine cytomegalovirus infection;    vaccination;    substance P;    sensory nerves;    neurogenic inflammation;   

DOI  :  10.1016/j.jaci.2019.01.031

来源: Elsevier

【 摘 要 】

Mast cells are highly versatile in terms of their mode of activation by a host of stimuli and their ability to flexibly release a plethora of biologically highly active mediators. Within the immune system, mast cells can best be designated as an active nexus interlinking innate and adaptive immunity. Here we try to draw an arc from initiation of acute inflammatory reactions to microbial pathogens to development of adaptive immunity and allergies. This multifaceted nature of mast cells is made possible by interaction with multiple cell types of immunologic and nonimmunologic origin. Examples for the former include neutrophils, eosinophils, T cells, and professional antigen-presenting cells. These interactions allow mast cells to orchestrate inflammatory innate reactions and complex adaptive immunity, including the pathogenesis of allergies. Important partners of nonimmunologic origin include cells of the sensory neuronal system. The intimate association between mast cells and sensory nerve fibers allows bidirectional communication, leading to neurogenic inflammation. Evidence is accumulating that this mast cell/nerve crosstalk is of pathophysiologic relevance in patients with allergic diseases, such as asthma.

【 授权许可】

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