JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 卷:121 |
Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-β levels after fish oil supplementation of pregnant women | |
Article | |
Krauss-Etschmann, Susanne1  Hard, Dominik1  Rzehak, Peter2,3  Heinrich, Joachim2  Shadid, Rania1  Ramirez-Tortosa, Maria Del Carmen4  Campoy, Cristina5  Pardillo, Susana5  Schendel, Dolores J.6,7,8  Decsi, Tamas9  Dernmelmair, Hans10  Koletzko, Berthold V.10  | |
[1] Univ Munich, Childrens Hosp, GSF, Natl Res Ctr Environm & Hlth,Clin Cooperat Grp, Neuherberg, Germany | |
[2] GSF, Natl Res Ctr Environm & Hlth, Inst Epidemiol, Neuherberg, Germany | |
[3] Univ Munich, Inst Med Data Management Biometr & Epidemiol, Munich, Germany | |
[4] Univ Granada, Dept Biochem, E-18071 Granada, Spain | |
[5] Univ Granada, Dept Mol Biol, E-18071 Granada, Spain | |
[6] Univ Granada, Dept Pediat, E-18071 Granada, Spain | |
[7] Nat Res Ctr Environm & Hlth, GSF, Inst Mol Immunol, Grosshadern, Germany | |
[8] Nat Res Ctr Environm & Hlth, GSF, Clin Coop Grp, Grosshadern, Germany | |
[9] Univ Pecs, Dept Pediat, Pecs, Hungary | |
[10] Univ Munich, Dr Von Hauner Childrens Hosp, Div Met Dis & Nutr, Munich, Germany | |
关键词: pregnancy; trial; fish oil; folate; cytokine; cord blood; allergy; neonate; | |
DOI : 10.1016/j.jaci.2007.09.018 | |
来源: Elsevier | |
【 摘 要 】
Background: Altered intakes of n-3 and n-6 polyunsaturated fatty acids were suggested to modulate allergic disease, but intervention trials yielded inconclusive results. Because allergies are primed in early infancy and in utero, the fetus might be more accessible to nutritional intervention strategies. Objective: We sought to investigate how supplementation of pregnant women with a fish oil (FO) preparation modulates allergy-related immune parameters in mothers and offspring. Methods: We performed a multicenter, randomized, double-blind, placebo-controlled trial. Three hundred eleven pregnant women received daily either FO with 0.5 g of docosahexaenoic acid and 0.15 g of eicosapentaenoic acid, 400 mu g of methyl-tetrahydrofolic acid, both, or placebo from the 22nd gestational week. T(H)1/T(H)2-related molecules were quantified in 197 maternal and 195 cord blood samples by using real-time RT-PCR. Data are given as geometric means [95% CIs]. Results: FO supplementation was associated with increased TGF-beta mRNA in maternal (0.85 [0.8-0.89]; placebo: 0.68 [0.64-0.72]) and cord blood (0.85 [0.81-0.9]; placebo: 0.75 [0.71-0.79]). IL-1 (0.69 [0.66-0.73]; placebo: 0.83 [0.79-0.88]) and IFN-gamma (0.54 [0.51-0.57]; placebo: 0.65 [0.61-0.69]) were decreased in mothers only (P<.001). Cord blood mRNA levels of IL-4 (0.54 [0.52-0.57]; placebo: 0.64 [0.61-0.68]), IL-13 (0.61 [0.58-0.65]; placebo: 0.85 [0.80-0.89]), CCR4 (0.70 [0.67-0.73]; placebo: 0.88 [0.84-0.92]; all P<.001), and natural killer (P<.001) and CCR3(+)CD8(+) T cells (P<.04) were decreased in the FO group. Conclusion: Supplementation with FO during pregnancy is associated with decreased mRNA levels of T(H)2-related molecules in the fetus and decreased maternal inflammatory cytokines. We speculate that both effects are mediated by TGF-beta.
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