Peanut, milk, and wheat intake during pregnancy is associated with reduced allergy and asthma in children

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:133

Article

Bunyavanich, Supinda^1,2,3  Rifas-Shiman, Sheryl L.^4,5  Platts-Mills, Thomas A.⁶  Workman, Lisa⁶  Sordillo, Joanne E.^5,7  Camargo, Carlos A., Jr.^5,7,8  Gillman, Matthew W.^4,5  Gold, Diane R.^5,7,9  Litonjua, Augusto A.^5,7,9 

[1] Icahn Sch Med Mt Sinai, Div Pediat Allergy & Immunol, Dept Pediat, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA

[3] Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA

[4] Harvard Pilgrim Hlth Care Inst, Dept Populat Med, Boston, MA USA

[5] Harvard Univ, Sch Med, Boston, MA USA

[6] Univ Virginia Hlth Syst, Asthma & Allerg Dis Ctr, Charlottesville, VA USA

[7] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA

[8] Massachusetts Gen Hosp, Dept Emergency Med, Boston, MA 02114 USA

[9] Brigham & Womens Hosp, Dept Med, Div Pulm & Crit Care Med, Boston, MA 02115 USA

关键词: Maternal diet;    pregnancy;    food allergy;    sensitization;    asthma;    allergic rhinitis;    peanut;    milk;    wheat;    childhood;   

DOI  :  10.1016/j.jaci.2013.11.040

来源: Elsevier

【 摘 要 】

Background: Maternal diet during pregnancy may affect childhood allergy and asthma. Objective: We sought to examine the associations between maternal intake of common childhood food allergens during early pregnancy and childhood allergy and asthma. Methods: We studied 1277 mother-child pairs from a US prebirth cohort unselected for any disease. Using food frequency questionnaires administered during the first and second trimesters, we assessed maternal intake of common childhood food allergens during pregnancy. In mid-childhood (mean age, 7.9 years), we assessed food allergy, asthma, allergic rhinitis, and atopic dermatitis by questionnaire and serum-specific IgE levels. We examined the associations between maternal diet during pregnancy and childhood allergy and asthma. We also examined the cross-sectional associations between specific food allergies, asthma, and atopic conditions in mid-childhood. Results: Food allergy was common (5.6%) in mid-childhood, as was sensitization to at least 1 food allergen (28.0%). Higher maternal peanut intake (each additional z score) during the first trimester was associated with 47% reduced odds of peanut allergic reaction (odds ratio [OR], 0.53; 95% CI, 0.30-0.94). Higher milk intake during the first trimester was associated with reduced asthma (OR, 0.83; 95% CI, 0.69-0.99) and allergic rhinitis (OR, 0.85; 95% CI, 0.74-0.97). Higher maternal wheat intake during the second trimester was associated with reduced atopic dermatitis (OR, 0.64; 95% CI, 0.46-0.90). Peanut, wheat, and soy allergy were each cross-sectionally associated with increased childhood asthma, atopic dermatitis, and allergic rhinitis (ORs, 3.6 to 8.1). Conclusion: Higher maternal intake of peanut, milk, and wheat during early pregnancy was associated with reduced odds of mid-childhood allergy and asthma.

【 授权许可】

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