Clinical Olfactory Working Group consensus statement on the treatment of postinfectious olfactory dysfunction

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:147

Article

Addison, Alfred B.¹  Wong, Billy¹  Ahmed, Tanzime¹  Macchi, Alberto²  Konstantinidis, Iordanis³  Huart, Caroline^4,5  Frasnelli, Johannes^6,7  Fjaeldstad, Alexander W.^8,9  Ramakrishnan, Vijay R.^10,11  Rombaux, Philippe^4,5  Whitcroft, Katherine L.^12,13  Holbrook, Eric H.¹⁴  Poletti, Sophia C.¹⁵  Hsieh, Julien W.¹⁶  Landis, Basile N.¹⁶  Boardman, James¹⁷  Welge-Lussen, Antje¹⁸  Maru, Devina¹⁹  Hummel, Thomas²⁰  Philpott, Carl M.^17,21,22 

[1] East Sussex North Essex Fdn Trust, Ipswich, Suffolk, England

[2] ENT Univ Insubria, Italian Acad Rhinol, Varese, Italy

[3] Aristotle Univ Thessaloniki, 2nd ORL Univ Dept, Smell & Taste Clin, Thessaloniki, Greece

[4] Clin Univ St Luc, Dept Otorhinolaryngol, Brussels, Belgium

[5] Catholic Univ Louvain, Inst Neurosci, Brussels, Belgium

[6] Univ Quebec Trois Rivieres, Dept Anat, Trois Rivieres, PQ, Canada

[7] Sacre Coeur Hosp Montreal, Res Ctr, Montreal, PQ, Canada

[8] Reg Hosp West Jutland, ENT Dept, Flavour Clin, Holstebro, Denmark

[9] Aarhus Univ, Flavour Inst, Aarhus, Denmark

[10] Univ Colorado, Dept Otolaryngol, Anschutz Med Campus, Aurora, CO USA

[11] Univ Colorado, Dept Neurosurg, Anschutz Med Campus, Aurora, CO USA

[12] Ctr Study Senses, Sch Adv Study, Inst Philosophy, London, England

[13] Yorkshire & Humber Sch Surg, South Yorkshire Deanery, Leeds, W Yorkshire, England

[14] Harvard Med Sch, Massachusetts Eye & Ear, Dept Otolaryngol Head & Neck Surg, Boston, MA 02115 USA

[15] Univ Bern, Bern Univ Hosp, Inselspital, Dept Otorhinolaryngol Head & Neck Surg, Bern, Switzerland

[16] Univ Hosp Geneva, Dept Otorhinolaryngol, Rhinol Olfactol Unit, Geneva, Switzerland

[17] Fifth Sense, Barrow In Furness, England

[18] Univ Basel, Univ Hosp Basel, Dept Otorhinolaryngol, Basel, Switzerland

[19] Royal Coll Gen Practitioners, London, England

[20] Tech Univ Dresden, Dept Otorhinolaryngol, Smell & Taste Clin, Dresden, Germany

[21] James Paget Univ Hosp NHS Fdn Trust, Norfolk Smell & Taste Clin, Gorleston, England

[22] Univ East Anglia, Norwich Med Sch, Norwich NR4 7TJ, Norfolk, England

关键词: Olfaction;    olfactory disorders;    viral infections;    hyposmia;    anosmia;    parosmia therapy;    COVID-19;   

DOI  :  10.1016/j.jaci.2020.12.641

来源: Elsevier

【 摘 要 】

Background: Respiratory tract viruses are the second most common cause of olfactory dysfunction. As we learn more about the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with the recognition that olfactory dysfunction is a key symptom of this disease process, there is a greater need than ever for evidence-based management of postinfectious olfactory dysfunction (PIOD). Objective: Our aim was to provide an evidence-based practical guide to the management of PIOD (including post-coronavirus 2019 cases) for both primary care practitioners and hospital specialists. Methods: A systematic review of the treatment options available for the management of PIOD was performed. The written systematic review was then circulated among the members of the Clinical Olfactory Working Group for their perusal before roundtable expert discussion of the treatment options. The group also undertook a survey to determine their current clinical practice with regard to treatment of PIOD. Results: The search resulted in 467 citations, of which 107 articles were fully reviewed and analyzed for eligibility; 40 citations fulfilled the inclusion criteria, 11 of which were randomized controlled trials. In total, 15 of the articles specifically looked at PIOD whereas the other 25 included other etiologies for olfactory dysfunction. Conclusions: The Clinical Olfactory Working Group members made an overwhelming recommendation for olfactory training; none recommended monocycline antibiotics. The diagnostic role of oral steroids was discussed; some group members were in favor of vitamin A drops. Further research is needed to confirm the place of other therapeutic options. (J Allergy Clin Immunol 2021;147:1704-19.)

【 授权许可】

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