Vitamin D supplementation attenuates asthma development following traffic-related particulate matter exposure

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:143

Article

Bolcas, Paige E.^2,3,4  Brandt, Eric B.²  Zhang, Zhonghua²  Myers, Jocelyn M. Biagini^1,2  Ruff, Brandy P.²  Hershey, Gurjit K. Khurana^1,2 

[1] Univ Cincinnati, Coll Med, Dept Pediat, Cincinnati, OH USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Asthma Res, Cincinnati, OH 45229 USA

[3] Cincinnati Childrens Hosp Med Ctr, Grad Program Immunol, Cincinnati, OH 45229 USA

[4] Univ Cincinnati, Coll Med, Cincinnati, OH USA

关键词: Vitamin D;    asthma;    diesel exhaust particle;    house dust mite;    traffic pollution;    allergen;    prevention;   

DOI  :  10.1016/j.jaci.2018.04.042

来源: Elsevier

【 摘 要 】

Background: Recent literature suggests that children who are vitamin D deficient are uniquely susceptible to the effects of traffic-related air pollution (TRAP) exposure. This is highly significant because large segments of the population reside in zones of high TRAP exposure. Objective: We sought to determine whether vitamin D supplementation mitigates the effect of TRAP exposure on asthma development, asthma exacerbation, and/or airway inflammation and to determine the timing of vitamin D supplementation that confers maximal health benefit. Methods: Using established mouse models of asthma, we examined the effect of prenatal and postnatal vitamin D supplementation on asthma development, as well as the utility of vitamin D as a treatment for established asthma in the context of diesel exhaust particle (DEP) exposure. Results: DEP and allergen coexposure resulted in increased airway hyperresponsiveness (AHR) and accumulation of pathogenic T(H)2/T(H)17 cells in the lungs of vitamin D-deficient mice compared with control mice. Prenatal and postnatal vitamin D supplementation significantly attenuated the development of AHR and decreased pulmonary accumulation of T(H)2/T(H)17 cells after coexposure to TRAP and allergen but not to allergen alone. Restoration of normal vitamin D status had no effect on AHR once asthma was already established. Conclusions: Our data establish that vitamin D confers protection against asthma development specifically in the context of TRAP exposure. Although vitamin D replacement did not reverse established asthma, restoration of normal vitamin D status in early life significantly attenuated the development of AHR in the setting of DEP-exacerbated allergic asthma and reduced numbers of lung T(H)2/T(H)17 cells, which portend the development of severe asthma.

【 授权许可】

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