Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunity

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:148

Article

Hagin, David¹  Freund, Tal¹  Navon, Michal⁴  Halperin, Tami^2,3  Adir, Dikla¹  Marom, Rotem^2,3  Levi, Inbar^2,3  Benor, Shira¹  Alcalay, Yifat¹  Freund, Natalia T.⁴ 

[1] Tel Aviv Univ, Allergy & Clin Immunol Unit, Dept Med, Tel Aviv, Israel

[2] Tel Aviv Univ, Lab HIV Diag AIDS Ctr, Tel Aviv Sourasky Med Ctr, Tel Aviv, Israel

[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel

[4] Tel Aviv Univ, Dept Clin Microbiol & Immunol, Sackler Fac Med, Tel Aviv, Israel

关键词: Inborn errors of immunity;    IEI;    primary immunodefi-ciency disorders;    PIDD;    SARS-CoV-2;    COVID-19;    vaccine;    Pfizer-BioNTech;    CVID;    XLA;    NFKB1;    STAT1-GOF;    STAT3-LOF;    HIES;    inhibiting antibodies;   

DOI  :  10.1016/j.jaci.2021.05.029

来源: Elsevier

【 摘 要 】

Background: In mid-December 2020, Israel started a nationwide mass vaccination campaign against coronavirus disease 2019 (COVID-19). In the first few weeks, medical personnel, elderly citizens, and patients with chronic diseases were prioritized. As such, patients with primary and secondary immunodeficiencies were encouraged to receive the vaccine. Although the efficacy of RNA-based COVID-19 vaccines has been demonstrated in the general population, little is known about their efficacy and safety in patients with inborn errors of immunity (IEI). Objective: Our aim was to evaluate the humoral and cellular immune response to COVID-19 vaccine in a cohort of patients with IEI. Methods: A total of 26 adult patients were enrolled, and plasma and peripheral blood mononuclear cells were collected from them 2 weeks following the second dose of Pfizer-BioNTech COVID-19 vaccine. Humoral response was evaluated by testing anti-SARS-CoV-2 spike (S) receptor-binding domain and antinucleocapsid antibody titers and evaluating neutralizing ability by inhibition of receptor-binding domain-angiotensin-converting enzyme 2 binding. Cellular immune response was evaluated by using ELISpot, estimating IL-2 and IFN-g secretion in response to pooled SARS-CoV-2 S-or M-peptides. Results: Our cohort included 18 patients with a predominantly antibody deficiency, 2 with combined immunodeficiency, 3 with immune dysregulation, and 3 with other genetically defined diagnoses. Twenty-two of them were receiving immunoglobulin replacement therapy. Of the 26 patients, 18 developed specific antibody response, and 19 showed S-peptide-specific T-cell response. None of the patients reported significant adverse events. Conclusion: Vaccinating patients with IEI is safe, and most patients were able to develop vaccine-specific antibody response, S-protein-specific cellular response, or both.

【 授权许可】

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