Corticosteroids depress IFN-α-producing plasmacytoid dendritic cells in human blood

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:108

Article

Shodell, M ; Siegal, FP

关键词: IFN-producing cells;    dendritic cells;    plasmacytoid;    corticosteroids;    steroid effects;    pDC;    immunosuppression;    T(H)1 immunity;    flow cytometry;   

DOI  :  10.1067/mai.2001.117928

来源: Elsevier

【 摘 要 】

Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-alpha in response to herpes simplex virus and by surface immunophenotyping. We here report that steroid administration results in a decrease of IFN-alpha generation of approximately 25-fold, accompanied by reduction in circulating plasmacytoid dendritic cell numbers. Both parameters return to normal within days after steroid cessation.

【 授权许可】

Free