A high-fat challenge increases airway inflammation and impairs bronchodilator recovery in asthma

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:127

Article

Wood, Lisa G.¹  Garg, Manohar L.²  Gibson, Peter G.^1,3 

[1] Univ Newcastle, Hunter Med Res Inst, Ctr Asthma & Resp Dis, Newcastle, NSW 2308, Australia

[2] Univ Newcastle, Nutraceut Res Grp, Sch Biomed Sci & Pharm, Newcastle, NSW 2308, Australia

[3] John Hunter Hosp, Dept Resp & Sleep Med, Newcastle, NSW, Australia

关键词: Dietary fat;    fatty acids;    neutrophils;    Toll-like receptor 4;    innate immunity;    asthma;    bronchodilator recovery;    airway inflammation;   

DOI  :  10.1016/j.jaci.2011.01.036

来源: Elsevier

【 摘 要 】

Background: Dietary fat activates systemic innate immune responses, but the effect on airway responses is unknown. Objective: To examine effects of a high-fat versus low-fat meal on systemic and airway inflammation in asthma. Methods: Nonobese subjects with asthma were randomized to consume a high-fat (n = 19; 48% [49 g] fat) or low-fat (n = 18; 15% [3 g] fat) meal. Fourteen obese patients with asthma and 21 healthy controls also consumed a high-fat meal. Another group of patients with asthma consumed a high-trans (n = 5; 5.2 g trans fat) or nontrans (n = 5, <0.3 g trans fat) fatty acid meal. Lung function was measured at baseline (prebronchodilator) and 2, 3, and 4 hours after bronchodilator. Airway inflammation was assessed by using induced sputum cell counts and Toll-like receptor 4 mRNA expression by real-time PCR. Systemic inflammation was measured by ELISA quantification of plasma TNF-alpha, high-sensitivity C-reactive protein, and IL-6 concentrations. Results: In patients with asthma, at 4 hours postmeal, increases in sputum % neutrophils and Toll-like receptor 4 mRNA expression were higher and increases in FEV1/forced vital capacity (FVC) were lower in the high-fat versus low-fat groups. Changes in plasma fatty acids correlated with changes in sputum % neutrophils and were negatively associated with changes in % FEV1, % FVC, and FEV1/FVC. After the high-trans fatty acid meal, sputum % neutrophils were significantly higher than after the nontrans meal. Conclusion: A high-fat meal augments neutrophilic airway inflammation, with the effect dependent on the type of fat consumed. A high-fat meal also suppresses bronchodilator recovery in asthma. Modifying dietary fat intake may be useful in asthma. (J Allergy Clin Immunol 2011;127:1133-40.)

【 授权许可】

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