Acute asthma intervention: Insights from the STAY study

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:119

Article

O'Byrne, Paul M.

关键词: asthma;    exacerbations;    inhaled corticosteroids;    budesonide;    long-acting beta-agonists;    formoterol;   

DOI  :  10.1016/j.jaci.2007.03.007

来源: Elsevier

【 摘 要 】

In some patients, asthma control is improved by combining inhaled corticosteroids with long-acting O-2-agonists. However, fluctuating asthma control and exacerbations can still occur. The STAY study evaluated whether, in patients with moderate to severe asthma, replacing a short-acting O-2-agonist reliever with the combination of budesonide/formoterol as reliever would both provide rapid symptom relief and reduce asthma exacerbations. The study evaluated 2760 patients with asthma (4-80 years) randomized to budesonide 400 mu g twice daily (bid) and terbutaline as reliever, budesonide/formoterol 100/6 mu g bid and terbutaline as reliever, or budesonide/formoterol 100/6 mu g bid both as maintenance and reliever. Children (age 4-11 years) used a once-daily maintenance dose. Budesonide/ formoterol as maintenance and reliever significantly reduced severe exacerbation risk by 45% to 47% compared with the other 2 treatments and improved symptoms, awakenings, and lung function. The benefit was seen in patients of all ages. Subsequent studies have revealed that this beneficial effect of budesonide/formoterol as maintenance and reliever requires both components of the combination.

【 授权许可】

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