Workshop report from the National Institutes of Health Taskforce on the Research Needs of Eosinophil-Associated Diseases (TREAD)

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:130

Article

Bochner, Bruce S.¹  Book, Wendy²  Busse, William W.³  Butterfield, Joseph⁴  Furuta, Glenn T.⁵  Gleich, Gerald J.⁶  Klion, Amy D.⁷  Lee, James J.⁸  Leiferman, Kristin M.⁶  Moqbel, Redwan⁹  Rothenberg, Marc E.¹⁰  Schwartz, Lawrence B.¹¹  Simon, Hans-Uwe¹²  Wechsler, Michael E.^13,14  Weller, Peter F.¹⁵ 

[1] Johns Hopkins Asthma & Allergy Ctr, Div Allergy & Clin Immunol, Dept Med, Baltimore, MD 21224 USA

[2] Amer Partnership Eosinophil Disorders, Atlanta, GA USA

[3] Univ Wisconsin, Dept Med, Sch Med & Publ Hlth, Div Clin Immunol & Allergy, Madison, WI USA

[4] Mayo Clin, Dept Med, Div Allerg Dis, Rochester, MN USA

[5] Univ Colorado, Sch Med,Sect Pediat Gastroenterol Hepatol & Nutr, Dept Pediat,Gastrointestinal Eosinophil Dis Progr, Childrens Hosp,Digest Hlth Inst,Natl Jewish Hlth, Aurora, CO USA

[6] Univ Utah, Hlth Sci Ctr, Dept Dermatol, Salt Lake City, UT USA

[7] NIAID, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[8] Mayo Clin Arizona, Div Pulm Med, Dept Biochem & Mol Biol, Scottsdale, AZ USA

[9] Univ Manitoba, Fac Med, Dept Immunol, Winnipeg, MB R3E 0W3, Canada

[10] Univ Cincinnati, Coll Med, Dept Pediat, Div Allergy & Immunol,Cincinnati Childrens Hosp M, Cincinnati, OH USA

[11] Virginia Commonwealth Univ, Dept Internal Med, Div Rheumatol Allergy & Immunol, Richmond, VA 23284 USA

[12] Univ Bern, Inst Pharmacol, Bern, Switzerland

[13] Brigham & Womens Hosp, Dept Med, Div Pulm & Crit Care, Boston, MA 02115 USA

[14] Harvard Univ, Sch Med, Boston, MA USA

[15] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Dept Med,Div Allergy & Inflammat,Div Infect Dis, Boston, MA 02215 USA

关键词: Eosinophil;    apoptosis;    therapeutics;    research;    discovery;    fusion oncoproteins;    hypereosinophilic syndromes;    Churg-Strauss syndrome;    coagulopathy;   

DOI  :  10.1016/j.jaci.2012.07.024

来源: Elsevier

【 摘 要 】

Background: Eosinophils are blood cells that are often found in high numbers in the tissues of allergic conditions and helminthic parasite infections. The pathophysiologic roles that eosinophils may serve in other human eosinophil-associated diseases remain obscure. Objective: National Institutes of Health (NIH) Institutes and the Office of Disease Prevention assembled an international taskforce of clinical and basic scientists with the charge to propose and prioritize unmet research needs in eosinophil-associated diseases. Methods: The taskforce used an organ system approach to identify the different and common themes of eosinophil cell involvement in these diseases. In early 2012, a draft document was circulated for review. The document was amended and the prioritizations were set at a NIH-organized workshop in June 2012. Results: The taskforce identified significant research needs. These needs cross disease entities but some are disease specific. There are substantial shortcomings to the various preclinical animal models, as well as significant gaps in our epidemiologic, pathophysiologic, diagnostic, prognostic, and therapeutic knowledge. The taskforce recognized that recent efforts by patient advocacy groups have played instrumental roles in improving the identification and characterization of these disorders. However, communications among the eosinophil-interested communities, for example, governmental funding and regulatory agencies, and industry and clinician scientists need to be more comprehensive. Conclusions: Significant efforts are required to address our knowledge gaps to improve the outcomes of eosinophil-associated diseases. NIH Institutes, other federal agencies, lay organizations, and the pharmaceutical industry should consider the taskforce's recommendations in their future research activities. (J Allergy Clin Immunol 2012;130:587-96.)

【 授权许可】

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