Food allergy: Insights into etiology, prevention, and treatment provided by murine models

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:133

Article

Oyoshi, Michiko K.^1,2  Oettgen, Hans C.^1,2  Chatila, Talal A.^1,2  Geha, Raif S.^1,2  Bryce, Paul J.³ 

[1] Boston Childrens Hosp, Div Immunol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Pediat, Boston, MA 02115 USA

[3] Northwestern Univ, Div Allergy Immunol, Feinberg Sch Med, Chicago, IL 60611 USA

关键词: Food allergy;    anaphylaxis;    murine model;    microbiota;    regulatory T cells;   

DOI  :  10.1016/j.jaci.2013.12.1045

来源: Elsevier

【 摘 要 】

Food allergy is a rapidly growing public health concern because of its increasing prevalence and life-threatening potential. Animal models of food allergy have emerged as a tool for identifying mechanisms involved in the development of sensitization to normally harmless food allergens, as well as delineating the critical immune components of the effector phase of allergic reactions to food. However, the role animal models might play in understanding human diseases remains contentious. This review summarizes how animal models have provided insights into the etiology of human food allergy, experimental corroboration for epidemiologic findings that might facilitate prevention strategies, and validation for the utility of new therapies for food allergy. Improved understanding of food allergy from the study of animal models together with human studies is likely to contribute to the development of novel strategies to prevent and treat food allergy.

【 授权许可】

Free