Breast-feeding in relation to asthma, lung function, and sensitization in young schoolchildren

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:125

Article

Kull, Inger^1,2  Melen, Erik^1,4  Alm, Johan^5,6  Hallberg, Jenny⁵  Svartengren, Magnus³  van Hage, Marianne⁷  Pershagen, Goran¹  Wickman, Magnus^1,5  Bergstrom, Anna¹ 

[1] Karolinska Inst, Inst Environm Med, SE-17176 Stockholm, Sweden

[2] Karolinska Inst, Ctr Allergy Res, SE-17176 Stockholm, Sweden

[3] Karolinska Inst, Dept Publ Hlth Sci, SE-17176 Stockholm, Sweden

[4] Karolinska Univ Hosp, Astrid Lindgren Childrens Hosp, Stockholm, Sweden

[5] Sachs Childrens Hosp, Dept Pediat, Stockholm, Sweden

[6] Soder Sjukhuset, Dept Clin Sci & Educ, Karolinska Inst, Stockholm, Sweden

[7] Karolinska Inst & Univ Hosp, Clin Immunol & Allergy Unit, Dept Med Solna, Stockholm, Sweden

关键词: Breast-feeding;    asthma;    sensitization;    lung function;    infant feeding;    prevention;    BAMSE;   

DOI  :  10.1016/j.jaci.2010.01.051

来源: Elsevier

【 摘 要 】

Background: The evidence from previous studies on beneficial effects of breast-feeding in relation to development of asthma is conflicting. Objective: To investigate the relation between breast-feeding and asthma and/or sensitization during the first 8 years of life. Method: In a birth cohort, children were followed up to 8 years by questionnaires at ages 2 months and 1, 2, 4, and 8 years to collect information on exposures and health effects. Determination of serum IgE antibodies to common inhalant and food allergens was performed at 4 and 8 years. Longitudinal analyses were applied by using general estimated equations. The study population consisted of 3825 children (93% of the original cohort), of whom 2370 gave blood and 2564 performed lung function measurements at 8 years. Results: Children exclusively breast-fed 4 months or more had a reduced risk of asthma during the first 8 years of life (adjusted odds ratio [OR], 0.63; 95% CI, 0.50-0.78) compared with children breast-fed less than 4 months. At 8 years, reduced risks of sensitization (adjusted OR, 0.79; 95% CI, 0.64-0.99) and asthma in combination with sensitization (adjusted OR, 0.59; 95% CI, 0.37-0.93) were seen among children exclusively breast-fed 4 months or more. This group also had a significantly better lung function measured with peak expiratory flow. Conclusion: Breast-feeding for 4 months or more seems to reduce the risk of asthma up to 8 years. At this age, a reduced risk was observed particularly for asthma combined with sensitization. Furthermore, breast-feeding seems to have a beneficial effect on lung function. (J Allergy Clin Immunol 2010;125:1013-9.)

【 授权许可】

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