Acculturation is associated with asthma burden and pulmonary function in Latino youth: The GALA II study

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:143

Article

Thakur, Neeta¹  Borrell, Luisa N.³  Ye, Morgan¹  Oh, Sam S.¹  Eng, Celeste¹  Meade, Kelley⁴  Avila, Pedro C.⁵  Farber, Harold J.^6,7  Serebrisky, Denise⁸  Brigino-Buenaventura, Emerita⁹  Rodriguez-Cintron, William¹⁰  Kumar, Rajesh¹¹  Bibbins-Domingo, Kirsten¹  Thyne, Shannon¹²  Sen, Saunak¹³  Rodriguez-Santana, Jose R.¹⁴  Burchard, Esteban G.^1,2 

[1] Univ Calif San Francisco, Dept Med, 550 16th St,2nd Floor, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Bioengn & Therapeut Sci, San Francisco, CA 94143 USA

[3] CUNY, Grad Sch Publ Hlth & Hlth Policy, Dept Epidemiol & Biostat, New York, NY 10021 USA

[4] Childrens Hosp & Res Ctr Oakland, Oakland, CA USA

[5] Allergy ENT & Associates, The Woodlands, TX USA

[6] Baylor Coll Med, Dept Pediat, Sect Pulmonol, Houston, TX 77030 USA

[7] Texas Childrens Hosp, Houston, TX 77030 USA

[8] Jacobi Med Ctr, Pediat Pulm Div, Bronx, NY USA

[9] Kaiser Permanente Vallejo Med Ctr, Dept Allergy & Immunol, Vallejo, CA USA

[10] Vet Caribbean Hlth Care Syst, San Juan, PR USA

[11] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA

[12] Univ Calif Los Angeles, Dept Pediat, Los Angeles, CA 90024 USA

[13] Univ Tennessee, Ctr Hlth Sci, Dept Prevent Med, Memphis, TN 38163 USA

[14] Ctr Neumol Pediat, San Juan, PR USA

关键词: Latino;    asthma;    acculturation;    pediatric;    health disparities;    social determinants of health;   

DOI  :  10.1016/j.jaci.2018.12.1015

来源: Elsevier

【 摘 要 】

Background: Acculturation is an important predictor of asthma in Latino youth, specifically Mexican Americans. Less is known about acculturation and pulmonary function measures. Objective: We sought to estimate the association of acculturation measures with asthma and pulmonary function in Latino youth and determine whether this association varies across Latino subgroups. Methods: We included 1849 Latinos (302 Caribbean Spanish, 193 Central or South Americans, 1136 Mexican Americans, and 218 other Latino children) aged 8 to 21 years from 4 urban regions in the United States. Acculturation measures include nativity status, age of immigration, language of preference, and generation in the United States. We used multivariable logistic and linear regression models to quantify the association of acculturation factors with the presence of asthma (case-control study) and pulmonary function (case-only study), adjusting for demographic, socioenvironmental, and clinical variables. Results: For all acculturation measures (nativity status, age of immigration, language of preference, and generation in the United States), greater levels of acculturation were associated with greater odds of asthma. Among cases, high (English preference) and medium (equal preference for Spanish and English) levels of language acculturation were associated with decreased bronchodilator response compared with low (Spanish preference) levels (P = .009 and .02, respectively). Similarly, high language acculturation was associated with increased FEV1 compared with low language acculturation (P = .02). There was insufficient evidence of heterogeneity for associations across Latino subgroups. Conclusions: Acculturation was associated with diagnosed asthma and pulmonary function in Latino children and is an important factor to consider in the management of Latino youth with asthma.

【 授权许可】

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