REPRODUCIBILITY OF ALLERGEN-INDUCED EARLY AND LATE ASTHMATIC RESPONSES

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:95

Article

INMAN, MD ; WATSON, R ; COCKCROFT, DW ; WONG, BJO ; HARGREAVE, FE ; OBYRNE, PM

关键词: ALLERGEN INHALATION CHALLENGE;    EARLY ASTHMATIC RESPONSE;    LATE ASTHMATIC RESPONSE;    REPRODUCIBILITY;    SAMPLE SIZE;   

DOI  :  10.1016/S0091-6749(95)70075-7

来源: Elsevier

【 摘 要 】

Background: Constant-dose allergen inhalation challenges are frequently used to examine the effect of antiasthma drugs on the allergen-induced early and late asthmatic responses. The end-point measurements in such studies ave the maximal early and late percent decreases in the forced expiratory volume in I second (FEV(1)). Objective: Our purpose was to observe the reproducibility and to determine the sample sizes required for such studies. Methods: Twenty-eight subjects with allergen-induced early and late responses were studied with two constant-dose allergen challenges separated by 2 to 12 weeks. The early response was measured as the maximum percent decrease in FEY(1) during the first 2 hours and the late response as the maximum percent decrease in FEV(1) between 3 to 7 hours. Results: The mean +/- SEM early responses were 23.1% +/- 1.0% and 24.7% +/- 2.0%, whereas the mean late responses were 23.3% +/- 2.0% and 24.5% +/- 2.2%. Reproducibility of measurements were such that fewer than eight subjects are required, to show 50% attenuation of either the early or late response (with 90% power). Conclusions: The method of constant-dose allergen challenge is a sensitive tool for detecting changes in early and late asthmatic responses after the use of antiasthma medication.

【 授权许可】

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