Chromosome 11q13.5 variant associated with childhood eczema: An effect supplementary to filaggrin mutations

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:125

Article

O'Regan, Grainne M.⁴  Campbell, Linda E.^2,3  Cordell, Heather J.⁵  Irvine, Alan D.^4,6  McLean, W. H. Irwin^1,2,3  Brown, Sara J.^2,3,4 

[1] Univ Dundee, Div Mol Med, Inst Med Sci, Epithelial Genet Grp,Coll Life Sci & Med, Dundee DD1 5EH, Scotland

[2] Univ Dundee, Div Mol Med, Coll Dent, Epithelial Genet Grp, Dundee DD1 5EH, Scotland

[3] Univ Dundee, Div Mol Med, Coll Nursing, Epithelial Genet Grp, Dundee DD1 5EH, Scotland

[4] Our Ladys Childrens Hosp, Dept Paediat Dermatol, Dublin, Ireland

[5] Newcastle Univ, Inst Human Genet, Newcastle Upon Tyne, Tyne & Wear, England

[6] Univ Dublin Trinity Coll, Inst Mol Med, Dublin 2, Ireland

关键词: Allergy;    atopic dermatitis;    atopy;    inflammatory skin disease;    skin barrier;   

DOI  :  10.1016/j.jaci.2009.10.046

来源: Elsevier

【 摘 要 】

Background: Atopic eczema is a common inflammatory skin disease with multifactorial etiology. The genetic basis is incompletely understood; however, loss of function mutations in the filaggrin gene (FLG) are the most significant and widely replicated genetic risk factor reported to date. The first genome-wide association study in atopic eczema recently identified 2 novel genetic variants in association with eczema susceptibility: a single nucleotide polymorphism on chromosome 11q13.5 (rs7927894) and a single nucleotide polymorphism (rs877776) within the gene encoding hornerin on chromosome 1q21. Objective: To test the association of these 2 novel variants with pediatric eczema and to investigate their interaction with FLG null mutations. Methods: Case-control study to investigate the association of rs7927894, rs877776 and the 4 most prevalent FLG null mutations with moderate-severe eczema in 511 Irish pediatric cases and 1000 Irish controls. Comprehensive testing for interaction between each of the loci was also performed. Results: The association between rs7927894 and atopic eczema was replicated in this population (P = .0025, chi(2) test; odds ratio, 1.27; 95% CI, 1.09-1.49). The 4 most common FLG null variants were strongly associated with atopic eczema (P = 1.26 x 10(-50); combined odds ratio, 5.81; 95% CI, 4.51-7.49). Interestingly, the rs7927894 association was independent of the well-established FLG risk alleles and may be multiplicative in its effect. There was no significant association between rs877776 and pediatric eczema in this study. Conclusion: Single nucleotide polymorphism rs7927894 appears to mark a genuine eczema susceptibility locus that will require further elucidation through fine mapping and functional analysis. (J Allergy Clin Immunol 2010;125:170-4.)

【 授权许可】

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