HLA-DQ8 and the HLA-DQ8-DR4 haplotype are positively associated with the hevein-specific IgE immune response in health care workers with latex allergy

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:110

Article

Rihs, HP ; Chen, ZP ; Ruëff, F ; Cremer, R ; Raulf-Heimsoth, M ; Baur, X ; Moneret-Vautrin, DA ; Brüning, T

关键词: latex allergy;    MHC class II association;    hevein;    HLA-DRB1*04;    DR4;    HLA-DQB1*0302;    DQ8;   

DOI  :  10.1067/mai.2002.127282

来源: Elsevier

【 摘 要 】

Background: Hevein is one of the most important latex allergens affecting health care workers (HCWs). Objective: Because the genetically determined susceptibility is one important factor regulating type I allergy, the association between the hevein-specific IgE immune response and HLA class II alleles of DQB1 and DRB1, DRB3, DRB4, and DRB5 was studied. Methods: The distribution of HLA-DQB1 and DRB1, DRB3, DRB4, and DRB5 in 269 HCWs with latex allergy, 56 latex-sensitized patients with spina bifida (SB), and 90 nonatopic control subjects under special consideration for hevein-specific IgE was examined. Results: Seventy percent (189/269) of the HCWs with latex allergy and 39% (22/56) of the latex-sensitized patients with SB had increased hevein-specific IgE antibody concentrations (>0.35 kU/L). HLA data analysis revealed significantly increased phenotype frequencies for DQB1*0302 (DQ8; 91/189 [48%]) and DRB1*04 (DR4; 102/189 [54%]) in hevein-positive HCWs with latex allergy compared with the 80 hevein-negative HCWs with latex allergy (DQB1*0302: 16/80 [20%], corrected P value [P-c] = 7.1 x 10(-4); DRB1*04: 23/80 [29%], P-c = .01) and with control subjects (DQB1*0302: 16/89 [18%], P-c 1 x 10(-4); DRB1*04: 22/90 [24%], P-c = 3.2 x 10(-4)). The DRB1*04 haplotype frequency was significantly elevated in HCWs with hevein-specific IgE antibodies when compared with that in HCWs without hevein-specific IgE antibodies (47% vs 18%, P-c = 5.3 x 10(-4)) or control subjects (47% vs 18%, P-c = 9.6 x 10(-4)). In contrast, latex-sensitized patients with SB with hevein-specific IgE antibodies showed an increased but not significant DQB1*0302 frequency (7/22 [32%] vs 2/34 [6%], P = .02, P-c = not significant) compared with that seen in those without hevein-specific IgE antibodies. Conclusion: The DQB1*0302 (DQ8) alone, the DQB1*0302 (DQ8)-DRB1*04 (DR4) haplotype, or both are significantly involved in the hevein-specific IgE immune response in HCWs with latex allergy.

【 授权许可】

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