Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:117

Article

Gern, JE ; Brooks, GD ; Meyer, P ; Chang, A ; Shen, KL ; Evans, MD ; Tisler, C ; DaSilva, D ; Roberg, KA ; Mikus, LD ; Rosenthal, LA ; Kirk, CJ ; Shult, PA ; Bhattacharya, A ; Li, ZH ; Gangnon, R ; Lemanske, RF

关键词: respiratory syncytial virus;    rhinoviruses;    wheezing;    IL-13;    cytokines;    viral infections;    bronchiolitis;    IFN-gamma;    atopy;    birth cohort;   

DOI  :  10.1016/j.jaci.2005.10.002

来源: Elsevier

【 摘 要 】

Background: Viral infections are the major cause of acute wheezing illnesses in childhood. Variations in immunologic responses at birth may be determinants of the risk of acquiring these illnesses. Objectives: To determine the immunologic risk factors for virus-induced wheezing in high-risk infants. Methods: The study involves 285 children with a parental history of asthma and/or respiratory allergies. Mononuclear cells obtained at birth (umbilical cord blood) and at 1 year of age were incubated with phytohemagglutinin, respiratory syncytial virus, or rhinovirus, and supernatants were analyzed for IL-5, IL-10, IL-13, and IFN-gamma. Nasal secretions obtained at well child visits and during respiratory illnesses were analyzed for common respiratory viruses. Results: Respiratory syncytial virus-induced wheezing was associated with reduced phytohemagglutinin-induced IL-13 responses (medians, 213 vs 304 mu g/mL; P = .026) from cord blood cells, and similar trends were found for wheezing in general. Furthermore, median IL-13 responses diminished by 28% in nonwheezing children by age 1 year, versus only 3% in wheezing children (P = .013). Children with >= 2 episodes of wheezing had lower phytohemagglutinin-induced IFN-gamma responses and were less likely to have rhinovirus-induced IFN-gamma responses at birth (P < .05). Finally, children with measurable cord blood IFN responses to respiratory syncytial virus were less likely to wheeze in their first year (odds ratio, 0.43 [0.23, 0.79]). Conclusion: In children with a family history of allergies and/or asthma, mononuclear cell phytohemagglutinin-induced IL-13 and virus-induced IFN-gamma responses at birth are indicative of the risk for wheezing in the first year of life.

【 授权许可】

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