Associations of cord blood fatty acids with lymphocyte proliferation, IL-13, and IFN-γ

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:117

Article

Gold, DR ; Willwerth, BM ; Tantisira, KG ; Finn, PW ; Schaub, B ; Perkins, DL ; Tzianabos, A ; Ly, NP ; Schroeter, C ; Gibbons, F ; Campos, H ; Oken, E ; Gillman, MW ; Palmer, LJ ; Ryan, LM ; Weiss, ST

关键词: asthma;    child;    cord blood;    cytokine;    fatty acids;    lymphocyte proliferation;   

DOI  :  10.1016/j.jaci.2005.12.1322

来源: Elsevier

【 摘 要 】

Background: N-3 and n-6 polyunsaturated fatty acids (PUFAs) have been hypothesized to have opposing influences on neonatal immune responses that might influence the risk of allergy or asthma. However, both n-3 eicosapentaenoic acid (EPA) and n-6 arachidonic acid (AA) are required for normal fetal development. Objective: We evaluated whether cord blood fatty acid levels were related to neonatal immune responses and whether n-3 and n-6 PUFA responses differed. Methods: We examined the relation of cord blood plasma n-3 and n-6 PUFAs (n = 192) to antigen- and mitogen-stimulated cord blood lymphocyte proliferation (n = 191) and cytokine (IL-13 and TFN-gamma; n = 167) secretion in a US birth cohort. Results: Higher levels of n-6 linoleic acid were correlated with higher IL-13 levels in response to Bla g 2 (cockroach, P = .009) and Der f 1 (dust mite, P = .02). Higher n-3 EPA and n-6 AA levels were each correlated with reduced lymphocyte proliferation and IFN-gamma levels in response to Bla g 2 and Der f 1 stimulation. Controlling for potential confounders, EPA and AA had similar independent effects on reduced allergen-stimulated IFN-gamma levels. If neonates had either EPA or AA levels in the highest quartile, their Der f 1 IFN-gamma levels were 90% lower (P = .0001) than those with both EPA and AA levels in the lowest 3 quartiles. Reduced AA/EPA ratio was associated with reduced allergen-stimulated IFN-gamma level. Conclusion: Increased levels of fetal n-3 EPA and n-6 AA might have similar effects on attenuation of cord blood lymphocyte proliferation and IFN-gamma secretion. Clinical implications: The implications of these findings for allergy or asthma development are not yet known.

【 授权许可】

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