The 3 major types of innate and adaptive cell-mediated effector immunity

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:135

Article

Annunziato, Francesco^1,2  Romagnani, Chiara³  Romagnani, Sergio^1,2 

[1] Univ Florence, Dept Expt & Clin Med, I-50139 Florence, Italy

[2] Univ Florence, DENOTHE Ctr, I-50139 Florence, Italy

[3] Deutsch Rheuma Forschungszentrum, Innate Immun, Berlin, Germany

关键词: Type 1 immunity;    type 2 immunity;    type 3 immunity;    innate lymphoid cells;    T(H)1;    T(C)1;    T(H)2;    T(C)2;    T(H)17/T(H)22;    T(C)17/T(C)22;   

DOI  :  10.1016/j.jaci.2014.11.001

来源: Elsevier

【 摘 要 】

The immune system has tailored its effector functions to optimally respond to distinct species of microbes. Based on emerging knowledge on the different effector T-cell and innate lymphoid cell (ILC) lineages, it is clear that the innate and adaptive immune systems converge into 3 major kinds of cellmediated effector immunity, which we propose to categorize as type 1, type 2, and type 3. Type 1 immunity consists of T-bet(+) IFN-gamma-producing group 1 ILCs (ILC1 and natural killer cells), CD8(+) cytotoxic T cells (T(C)1), and CD4(+) T(H)1 cells, which protect against intracellular microbes through activation of mononuclear phagocytes. Type 2 immunity consists of GATA-3(+) ILC2s, T(C)2 cells, and T(H)2 cells producing IL-4, IL-5, and IL-13, which induce mast cell, basophil, and eosinophil activation, as well as IgE antibody production, thus protecting against helminthes and venoms. Type 3 immunity is mediated by retinoic acid-related orphan receptor gamma t(+) ILC3s, T(C)17 cells, and T(H)17 cells producing IL-17, IL-22, or both, which activate mononuclear phagocytes but also recruit neutrophils and induce epithelial antimicrobial responses, thus protecting against extracellular bacteria and fungi. On the other hand, type 1 and 3 immunity mediate autoimmune diseases, whereas type 2 responses can cause allergic diseases.

【 授权许可】

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