The prevalence of plant food allergies: A systematic review

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:121

Article

Zuidmeer, Laurian¹  Goldhahn, Klaus²  Rona, Roberto J.³  Gislason, David⁴  Madsen, Charlotte⁵  Summers, Colin⁶  Sodergren, Eva⁷  Dahlstrom, Jorgen⁷  Lindner, Titia⁸  McBride, Doreen²  Keil, Thomas² 

[1] Acad Med Ctr, Dept Expt Immunol, Lab Allergy, NL-1105 AZ Amsterdam, Netherlands

[2] Univ Med Ctr Berlin, Charite, Inst Social Med Epidemiol & Hlth Econ, Berlin, Germany

[3] Kings Coll London, Div Asthma Allergy & Lung Biol, London, England

[4] Dept Allergy Resp Med & Sleep, Reykjavik, Iceland

[5] Tech Univ Denmark, Natl Food Inst, Dept Toxicol & Risk Assessment, DK-2800 Lyngby, Denmark

[6] Manchester Royal Infirm, Dept Immunol, Allergy Res Grp, Manchester, Lancs, England

[7] Phadia AB, Uppsala, Sweden

[8] Univ Med Ctr Utrecht, Dept Dermatol & Allergol, Utrecht, Netherlands

关键词: cereal;    EuroPrevall;    food allergy;    food hypersensitivity;    fruit;    meta-analysis;    nuts;    prevalence;    seeds;    soy;    vegetables;    wheat;   

DOI  :  10.1016/j.jaci.2008.02.019

来源: Elsevier

【 摘 要 】

Background: There is uncertainty regarding the prevalence of allergies to plant food. Objective: To assess the prevalence of allergies to plant food according to the different subjective and objective assessment methods. Methods: Our systematic search of population-based studies (since 1990) in the literature database MEDLINE focused on fruits, vegetables/legumes, tree nuts, wheat, soy, cereals, and seeds. Prevalence estimates were categorized by food item and method used (food challenges, skin prick test, serum IgE, parent/self-reported symptoms), complemented by appropriate meta-analyses. Results: We included 36 studies with,data from a total of over 250,000 children and adults. Only 6 studies included food challenge tests with prevalences ranging from 0.1% to 4.3% each for fruits and tree nuts, 0.1% to 1.4% for vegetables, and <1% each for wheat, soy, and sesame. The prevalence of sensitization against any specific plant food item assessed by skin prick test was usually < 1 %, whereas sensitization assessed by IgE against wheat ranged as high as 3.6% and against soy as high as 2.9%. For fruit and vegetables, prevalences based on perception were generally higher than those based on sensitization, but for wheat and soy in adults, sensitization was higher. Meta-analyses showed significant heterogeneity between studies regardless of food item or age group. Conclusion: Population-based prevalence estimates for allergies to plant products determined by the diagnostic gold standard are scarce. There was considerable heterogeneity in the prevalence estimates of sensitization or perceived allergic reactions to plant food.

【 授权许可】

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