National prevalence and risk factors for food allergy and relationship to asthma: Results from the National Health and Nutrition Examination Survey 2005-2006

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:126

Article

Liu, Andrew H.^1,2  Jaramillo, Renee³  Sicherer, Scott H.⁴  Wood, Robert A.⁵  Bock, S. Allan^1,2  Burks, A. Wesley⁶  Massing, Mark³  Cohn, Richard D.³  Zeldin, Darryl C.⁷ 

[1] Natl Jewish Hlth, Denver, CO 80206 USA

[2] Univ Colorado, Denver Sch Med, Denver, CO 80202 USA

[3] SRA Int Inc, Durham, NC USA

[4] Mt Sinai Sch Med, Jaffe Food Allergy Inst, New York, NY USA

[5] Johns Hopkins Univ, Sch Med, Baltimore, MD USA

[6] Duke Univ, Med Ctr, Durham, NC USA

[7] NIEHS, NIH, Res Triangle Pk, NC 27709 USA

关键词: Asthma;    eczema;    egg;    food allergy;    food sensitization;    food-specific serum IgE;    peanut;    hay fever;    milk;    prevalence;    risk;    shrimp;   

DOI  :  10.1016/j.jaci.2010.07.026

来源: Elsevier

【 摘 要 】

Background: The national prevalence and patterns of food allergy (FA) in the United States are not well understood. Objective: We developed nationally representative estimates of the prevalence of and demographic risk factors for FA and investigated associations of FA with asthma, hay fever, and eczema. Methods: A total of 8203 participants in the National Health and Nutrition Examination Survey 2005-2006 had food-specific serum IgE measured to peanut, cow's milk, egg white, and shrimp. Food-specific IgE and age-based criteria were used to define likely FA (LFA), possible FA, and unlikely FA and to develop estimates of clinical FA. Self-reported data were used to evaluate demographic risk factors and associations with asthma and related conditions. Results: In the United States, the estimated prevalence of clinical FA was 2.5% (peanut, 1.3%; milk, 0.4%; egg, 0.2%; shrimp, 1.0%; not mutually exclusive). Risk of possible FA/LFA was increased in non-Hispanic blacks (odds ratio, 3.06; 95% CI, 2.14-4.36), males (1.87; 1.32-2.66), and children (2.04; 1.42-2.93). Study participants with doctor-diagnosed asthma (vs no asthma) exhibited increased risk of all measures of food sensitization. Moreover, in those with LFA, the adjusted odds ratio for current asthma (3.8; 1.5-10.7) and an emergency department visit for asthma in the past year (6.9; 2.4-19.7) were both notably increased. Conclusion: Population-based serologic data on 4 foods indicate an estimated 2.5% of the US population has FA, and increased risk was found for black subjects, male subjects, and children. In addition, FA could be an under-recognized risk factor for problematic asthma. (J Allergy Clin Immunol 2010;126:798-806.)

【 授权许可】

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