Probiotic milk consumption in pregnancy and infancy and subsequent childhood allergic diseases

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

卷:133

Article

Bertelsen, Randi J.^1,5  Brantsaeter, Anne Lise²  Magnus, Maria C.^3,5  Haugen, Margaretha²  Myhre, Ronny⁴  Jacobsson, Bo^4,6  Longnecker, Matthew P.⁵  Meltzer, Helle M.²  London, Stephanie J.⁵ 

[1] Norwegian Inst Publ Hlth, Dept Food Water & Cosmet, N-0403 Oslo, Norway

[2] Norwegian Inst Publ Hlth, Dept Exposure & Risk Assessment, N-0403 Oslo, Norway

[3] Norwegian Inst Publ Hlth, Dept Chron Dis, N-0403 Oslo, Norway

[4] Norwegian Inst Publ Hlth, Dept Genes & Environm, N-0403 Oslo, Norway

[5] NIEHS, Epidemiol Branch, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA

[6] Sahlgrens Acad, Dept Obstet & Gynecol, Gothenburg, Sweden

关键词: Allergy;    asthma;    eczema;    microbiome;    Norwegian Mother and Child Cohort Study;    probiotics;    rhinoconjunctivitis;   

DOI  :  10.1016/j.jaci.2013.07.032

来源: Elsevier

【 摘 要 】

Background: Whether probiotics, which can influence the microbiome, prevent infant eczema or allergic disease remains an open question. Most studies have focused on high-risk infants. Objectives: We sought to assess whether consumption of probiotic milk products protects against atopic eczema, rhinoconjunctivitis, and asthma in early childhood in a large population-based pregnancy cohort (the Norwegian Mother and Child Cohort study). Methods: We examined associations between consumption of probiotic milk products in pregnancy and infancy with questionnaire-reported atopic eczema, rhinoconjunctivitis, and asthma in 40,614 children. Relative risks (RRs) were calculated by using general linear models adjusted for potential confounders. Results: Consumption of probiotic milk in pregnancy was associated with a slightly reduced relative risk (RR) of atopic eczema at 6 months (adjusted RR, 0.94; 95% CI, 0.89-0.99) and of rhinoconjunctivitis between 18 and 36 months (adjusted RR, 0.87; 95% CI, 0.78-0.98) compared with no consumption during pregnancy. Maternal history of allergic disease did not notably influence the associations. When both the mother (during pregnancy) and infant (after 6 months of age) had consumed probiotic milk, the adjusted RR of rhinoconjunctivitis was 0.80 (95% CI, 0.68-0.93) relative to no consumption by either. Probiotic milk consumption was not associated with asthma at 36 months. Conclusions: In this population-based cohort consumption of probiotic milk products was related to a reduced incidence of atopic eczema and rhinoconjunctivitis, but no association was seen for incidence of asthma by 36 months of age.

【 授权许可】

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