Bioinspired bactericidal surfaces with polymer nanocone arrays

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:528

Article

Hazell, Gavin¹  Fisher, Leanne E.¹  Murray, W. Andrew²  Nobbs, Angela H.¹  Su, Bo¹ 

[1] Univ Bristol, Bristol Dent Sch, Bristol BS1 2LY, Avon, England

[2] Univ Bristol, Sch Phys, Bristol BS8 1TL, Avon, England

关键词: Biomaterials;    Nanotopography;    Bioinspired;    Bactericidal;    Nanocone;   

DOI  :  10.1016/j.jcis.2018.05.096

来源: Elsevier

【 摘 要 】

Infections resulting from bacterial biofilm formation on the surface of medical devices are challenging to treat and can cause significant patient morbidity. Recently, it has become apparent that regulation of surface nanotopography can render surfaces bactericidal. In this study, poly(ethylene terephthalate) nano cone arrays are generated through a polystyrene nanosphere-mask colloidal lithographic process. It is shown that modification of the mask diameter leads to a direct modification of centre-to-centre spacing between nanocones. By altering the oxygen plasma etching time it is possible to modify the height, tip width and base diameter of the individual nanocone features. The bactericidal activity of the nanocone arrays was investigated against Escherichia coli and Klebsiella pneumoniae. It is shown that surfaces with the most densely populated nanocone arrays (center-to-center spacing of 200 nm), higher aspect ratios (>3) and tip widths <20 nm kill the highest percentage of bacteria (similar to 30%). (C) 2018 Elsevier Inc. All rights reserved.

【 授权许可】

Free