Tuning morphology of Pickering emulsions stabilised by biodegradable PLGA nanoparticles: How PLGA characteristics influence emulsion properties

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:595

Article

Robin, Baptiste¹  Albert, Claire¹  Beladjine, Mohamed¹  Legrand, Francois-Xavier¹  Geiger, Sandrine^1,4  Moine, Laurence¹  Nicolas, Valerie²  Canette, Alexis³  Trichet, Michael³  Tsapis, Nicolas¹  Agnely, Florence¹  Huang, Nicolas¹ 

[1] Univ Paris Saclay, CNRS, Inst Galien Paris Saclay, F-92296 Chatenay Malabry, France

[2] Univ Paris Saclay, Microscopy Facil MIPSIT Ingn & Plateformes Serv I, IPSIT, UMS,US31,UMS3679,IPSIT, Chatenay Malabry, France

[3] Sorbonne Univ, CNRS, Inst Biol Paris Seine IBPS, Serv Microscopie Elect IBPS SME, F-75005 Paris, France

[4] Univ Paris Saclay, Struct Proprietes & Modelisat Solides SPMS, Cent Supelec, CNRS,UMR 8580, 3 Rue Joliot Curie, Gif Sur Yvette, France

关键词: Pickering emulsions;    PLGA;    Nanoparticles;    Polymer end group;    Molar mass;    PVA;    Wettability;    Glass transition temperature;    Emulsion type;    Nanoparticle organisation;   

DOI  :  10.1016/j.jcis.2021.03.061

来源: Elsevier

【 摘 要 】

In this study, we proved that the stabilisation of Pickering emulsions by polymer nanoparticles (NPs) heavily depends on polymer characteristics. We prepared NPs with four poly(lactide-co-glycolide) polymers (PLGA), of different molar masses (14,000 and 32,000 g/mol) and end groups (acid or alkylester). NPs were either bare (without stabilising polymer) or covered by polyvinyl alcohol (PVA). Pickering emulsions were prepared by mixing NP aqueous suspensions with various amounts of oil (Miglyol 812 N). First, NP wettability was directly affected by PLGA end group: ester-ending PLGA led to more hydrophobic NPs, compared to acid-ending PLGA. This effect of the end group could be slightly enhanced with smaller molar mass. Thus, bare PLGA NPs stabilised different types of emulsions (W/O/W and W/O), following Finkle's rule. However, the effect of PLGA characteristics was masked when NPs were covered by PVA, as PVA drove the stabilisation of O/W emulsions. Secondly, PLGA molar mass and end group also influenced its glass transition temperature (T-g), with spectacular consequences on emulsion formation. Indeed, the shortest ester-ending PLGA exhibited a T-g close to room temperature, when measured in the emulsion. This T-g, easily exceeded during emulsification process, led to a soft solid emulsion, stabilised by a network of NP debris. (C) 2021 Elsevier Inc. All rights reserved.

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