Supramolecular architecture of a multi-component biomimetic lipid barrier formulation

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:587

Article

Ahmadi, Delaram¹  Ledder, Ruth²  Mahmoudi, Najet³  Li, Peixun³  Tellam, James³  Robinson, Douglas³  Heenan, Richard K.³  Smith, Paul⁴  Lorenz, Christian D.⁴  Barlow, David J.^1,2  Lawrence, M. Jayne² 

[1] Kings Coll London, Inst Pharmaceut Sci, Franklin Wilkins Bldg,150 Stamford St, London SE1 9NH, England

[2] Univ Manchester, Sch Hlth Sci, Div Pharm & Optometry, Stopford Bldg,Oxford Rd, Manchester M13 9PG, Lancs, England

[3] Rutherford Appleton Lab, STFC ISIS Facil, Didcot OX11 0QX, Oxon, England

[4] Kings Coll London, Dept Phys, London WC2R 2LS, England

关键词: Small angle neutron scattering;    Biomimetic skin creams;    Molecular dynamics;    Antimicrobial preservatives;    Soft matter;    Colloidal systems;    Liquid crystalline structures;   

DOI  :  10.1016/j.jcis.2020.11.017

来源: Elsevier

【 摘 要 】

Hypothesis: Biomimetic liquid crystalline systems are widely used in skin care cosmetics and topical pharmaceutical preparations. Our ability to rationally design such formulations, however, is hampered by our incomplete understanding of their structure on the nanoscale. Experiments: Using polarized light microscopy and small-angle and wide-angle X-ray scattering, the molecular architecture and properties of a barrier formulation prepared from distearoylphosphatidylcholine mixed with long chain fatty acid and alcohols, with and without antimicrobial pentanediols are directly probed. The nature and composition of the phases identified are determined through small-angle neutron scattering studies using chain-deuterated components, and the detailed structure and dynamics of the gel network lamellae are determined through molecular dynamics simulations. Findings: The formulations show molecular ordering with long and short periodicity lamellar phases and there is little change in these structures caused by changes in temperature, drying, or the application of shear stress. The diol-free formulation is demonstrated to be self-preserving, and the added pentanediols are shown to distribute within the interlamellar regions where they limit availability of water for microbial growth. In culmination of these studies, we develop a more complete picture of these complex biomimetic preparations, and thereby enable their structure-based design. (c) 2020 Elsevier Inc. All rights reserved.

【 授权许可】

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