ABA-type triblock copolymer micellar system with lower critical solution temperature-type sol-gel transition

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:545

Article

Shi, Haotian¹  Qiu, Teng^1,2  Ou-Yang, H. Daniel^3,4  Xu, Huangbing²  Lu, Qingchuan¹  Zheng, Ying⁵  Liu, Kexin⁵  He, Lifan^1,2  Guo, Longhai^1,2  Li, Xiaoyu^1,2 

[1] Beijing Univ Chem Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China

[2] Beijing Univ Chem Technol, Beijing Engn Res Ctr Synth & Applicat Waterborne, Beijing 100029, Peoples R China

[3] Lehigh Univ, Dept Phys, Bioengn Dept, Bldg 16, Bethlehem, PA 18015 USA

[4] Lehigh Univ, Emuls Polymers Inst, Bethlehem, PA 18015 USA

[5] Univ Chinese Acad Sci, Shenzhen Hosp, Shenzhen 518107, Peoples R China

关键词: RAFT polymerization;    Block copolymer;    Self-assembly;    LCST;    Morphology;    Drug delivery;   

DOI  :  10.1016/j.jcis.2019.03.039

来源: Elsevier

【 摘 要 】

A temperature sensitive sol-gel transition induced by the self-assembly of amphiphilic copolymers and its application in industry have been the objects of increasing study. We demonstrate here a two-step, reversible addition-fragmentation chain transfer (RAFT) polymerization of an ABA-type copolymer consisting of poly(N,N-dimethylacrylamide)-b-poly(diacetone acrylamide)-b-poly(N,N-dimethylacrylamide) (PDMAA-b-PDAAM-b-PDMAA). This copolymer can be easily dispersed in water, and this dispersion is critical for its lower critical solution temperature (LCST)-type sol-gel transition, which was monitored using dynamic light scattering (DLS), transmission electron microscopy (TEM), and rheology analysis, in addition to temperature-dependent H-1 nuclear magnetic resonance (H-1 NMR) and Fourier transform infrared spectroscopy (FTIR). Results revealed an abnormal sphere-to-worm micellar transition of this ABA copolymer at the LCST point, which could be affected by the length of the PDAAM block (B-block), the length as well as the distribution of the PDMAA block (A-block), and the concentration of the copolymer dispersion. Thus, copolymer dispersion could be feasibly used for drug loading at a low temperature, which could then be transformed into a gel at an elevated temperature. The loading and controllable release of the model drug of paracetamol into and out of a copolymer gel was further determined. The sustained release behavior was also studied using the Rigter-Peppas model. (C) 2019 Elsevier Inc. All rights reserved.

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