Novel agrochemical conjugates with self-assembling behaviour

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:512

Article

Liu, Qingtao^1,2  Graham, Bim³  Hawley, Adrian⁴  Dong, Yao-Da¹  Boyd, Ben J.^1,2 

[1] Monash Univ, Monash Inst Pharmaceut Sci, Drug Delivery Disposit & Dynam, Parkville Campus,381 Royal Parade, Parkville, Vic 3052, Australia

[2] Monash Univ, Monash Inst Pharmaceut Sci, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville Campus,381 Royal Parade, Parkville, Vic 3052, Australia

[3] Monash Univ, Monash Inst Pharmaceut Sci, Med Chem, Parkville Campus,381 Royal Parade, Parkville, Vic 3052, Australia

[4] Australian Synchrotron, WAXS Beamline, SAXS, Clayton, Vic, Australia

关键词: Lyotropic liquid crystal;    Agricultural chemical;    Self assembly;   

DOI  :  10.1016/j.jcis.2017.10.070

来源: Elsevier

【 摘 要 】

Hypothesis: That conjugation of agrichemicals to pro-assembly hydrophobic moieties will enable enhanced compatibility and loading with host lyotropic liquid crystalline carrier matrix, and potentially self-assemble in their own right in aqueous environments. Experiments: A series of lipid-likeagrochemical-conjugates were synthesized using specific amphiphilic entities conjugated onto the agro-chemicals, picloram and 2,4-dichlorophenoxyacetic acid (2,4-D). The self-assembly behaviour and compatibility of the novel entities when incorporated into phytantriol and monoolein-based liquid crystalline systems were examined using small angle X-ray scattering, cryo-TEM and polarized optical microscopy. Findings: Compared to agrochemical-conjugates with simple alkyl ester groups, the esterification of the agrochemicals with amphiphilic groups such as phytantriol and monoolein led to greater structural compatibility and consequently a greater loading of the agrochemicals in the liquid crystalline systems without destabilizing phase structure. Picloram-monoolein and picloram-monoelaidin can self-assemble to form lamellar structures in water. However, certain agrochemical-conjugates such as picloram-monoelaidin and picloram-PEGn-oleate showed poor compatibility with liquid crystalline systems, resulting in phase separation. (C) 2017 Elsevier Inc. All rights reserved.

【 授权许可】

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