Efficient drug delivery using SiO2-layered double hydroxide nanocomposites

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:470

Article

Li, Li¹  Gu, Zi^1,2  Gu, Wenyi¹  Liu, Jian³  Xu, Zhi Ping¹ 

[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, Brisbane, Qld 4072, Australia

[2] Univ New S Wales, Sch Chem Engn, Sydney, NSW 2052, Australia

[3] Curtin Univ, Dept Chem Engn, Bentley, WA, Australia

关键词: Layered double hydroxide (LDH);    Functionalization;    Drug delivery;    Nanocomposites;    Self-assembly;   

DOI  :  10.1016/j.jcis.2016.02.042

来源: Elsevier

【 摘 要 】

MgAl-layered double hydroxide (MgAI-LDH) nanoparticles have great potentials in drug and siRNA delivery. In this work, we used a nanodot-coating strategy to prepare SiO2 dot-coated layered double hydroxide (SiO2@MgAl-LDH) nanocomposites with good dispersibility and controllable size for drug delivery. The optimal SiO2@MgAl-LDH nanocomposite was obtained by adjusting synthetic parameters including the mass ratio of MgAl-LDH to SiO2, the mixing temperature and time. The optimal SiO2@MgAl-LDH nanocomposite was shown to have SiO2 nanodots (10-15 nm in diameter) evenly deposited on the surface of MgAl-LDHs (110 nm in diameter) with the plate-like morphology and the average hydrodynamic diameter of 170 nm. We further employed SiO2@MgAl-LDH nanocomposite as a nanocarrier to deliver methotrexate (MTX), a chemotherapy drug, to the human osteosarcoma cell (U2OS) and found that MTX delivered by SiO2@MgAl-LDH nanocomposite apparently inhibited the U2OS cell growth. (C) 2016 Elsevier Inc. All rights reserved.

【 授权许可】

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