Controlled release of bupivacaine using hybrid thermoresponsive nanoparticles activated via photothermal heating

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:523

Article

Alejo, Teresa^1,2  Andreu, Vanesa^1,2  Mendoza, Gracia^1,2  Sebastian, Victor^1,2,3  Arruebo, Manuel^1,2,3 

[1] Univ Zaragoza, Aragon Inst Nanosci INA, Dept Chem Engn, Campus Rio Ebro,Edificio I D, Zaragoza 50018, Spain

[2] Aragon Hlth Res Inst IIS Aragon, Zaragoza 50009, Spain

[3] CIBER BBN, Networking Res Ctr Bioengn Biomat & Nanomed, Madrid 28029, Spain

关键词: Thermoresponsive polymer;    Phototriggerable;    On-demand;    Plasmonic nanoparticles;    Anesthetic drug;   

DOI  :  10.1016/j.jcis.2018.03.107

来源: Elsevier

【 摘 要 】

Near-infrared (NIR) responsive nanoparticles are of great interest in the biomedical field as antennas for photothermal therapy and also as triggers for on-demand drug delivery The present work reports the preparation of hollow gold nanoparticles (HGNPs) with plasmomc absorption in the NIR region covalently bound to a thermoresponsive polymeric shell that can be used as an on-demand drug delivery system for the release of analgesic drugs. The photothermal heating induced by the nanoparticles is able to produce the collapse of the polymeric shell thus generating the release of the local anesthetic bupivacaine in a spatiotemporally controlled way. Those HGNPs contain a 10 wt % of polymer and present excellent reversible heating under NIR light excitation. Bupivacaine released at physiological temperature (37 degrees C) showed a pseudo-zero order release that could be spatiotemporally modified on-demand after applying several pulses of light/temperature above and below the lower critical solution temperature (LCST) of the polymeric shell Furthermore, the nanomaterials obtained did not displayed detrimental effects on four mammalian cell lines at doses up to 0.2 mg/mL. From the results obtained it can be concluded than this type of hybrid thermoresponsive nanoparticle can be used as an externally activated on-demand drug delivery system. (C) 2018 Elsevier Inc All rights reserved.

【 授权许可】

Free