Multicharge zwitterionic molecules: Hydration, kosmotropicity and anti-fouling potential

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:562

Article

Level, Gaelle¹  Zhang, Jiaxin²  Brown, John³  Hammond, Oliver¹  Hannigan, Brian³  Stella, Lorenzo^2,3  Nockemann, Peter¹  Blesic, Marijana¹ 

[1] Queens Univ Belfast, QUILL Res Ctr, Sch Chem & Chem Engn, Stranmillis Rd, Belfast BT9 5AG, Antrim, North Ireland

[2] Queens Univ Belfast, Atomist Simulat Ctr, Sch Math & Phys, Univ Rd, Belfast BT7 1NN, Antrim, North Ireland

[3] Queens Univ Belfast, Sch Chem & Chem Engn, Stranmillis Rd, Belfast BT9 5AG, Antrim, North Ireland

关键词: Aqueous solution;    Zwitterion;    Zwitterionic salt;    Tetraalkylammonium;    Surface tension;    Viscosity;    Density;    Jones-Dole viscosity B-coefficient;    Protein;    Solubility;    Amino acid;   

DOI  :  10.1016/j.jcis.2019.12.009

来源: Elsevier

【 摘 要 】

This manuscript presents a comparative study of the physico-chemical behaviour of sulfobetaine-type single and double zwitterions and zwitterionic salts, and structurally similar mono- and di-cationic tetraalkylammonium salts in aqueous solutions. The study includes experimental determination of the density and viscosity of highly diluted aqueous solutions with derivation of the Jones-Dole viscosity B-coefficient, partial molal volumes at infinite dilution, and hydration numbers. The study also examines the effects of addition of the salts on the surface tension of cationic and anionic surfactants, upper critical solution temperature of a non-ionic surfactant, solubility of amino acids, and stability of a protein. The experimental investigation was performed taking a broad bottom-up approach with the aim to elucidate the effect of molecular architecture and charge (two versus four) on the degree of surface hydration of a molecule, kosmotropicity, and interactions with charged and hydrophilic/hydrophobic surfaces - all-important characteristics which define ability of a functional group to resist protein attachment. The novel multicharged zwitterionic materials have exhibited superior qualities, thus paving the way to development of a new platform in design of hydrophilic and anti-fouling surfaces by employing the four-charge bearing molecular motifs. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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