Synthesis and pH-dependent micellization of diblock copolymer mixtures

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:329

Article

Van Butsele, K.¹  Sibret, P.¹  Fustin, C. A.²  Gohy, J. F.²  Passirani, C.³  Benoit, J. -P.³  Jerome, R.¹  Jerome, C.¹ 

[1] Univ Liege, Ctr Educ & Res Macromol, B-4000 Liege, Belgium

[2] Catholic Univ Louvain, Unite CMAT, B-1348 Louvain, Belgium

[3] INSERM, U 646, F-49000 Angers, France

关键词: Micelle;    Copolymer;   

DOI  :  10.1016/j.jcis.2008.09.080

来源: Elsevier

【 摘 要 】

This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(epsilon-caprolactone) (PCL) core and a mixed shell of hydrophilic poly(ethylene oxide) (PEO) and pH-sensitive poly(2-vinylpyridine) (P2VP). The hybrid micelles were successfully prepared by the rapid addition of acidic water to a binary solution of PCL34-b-PEO114 and PCL32-b-P2VP(52) diblock copolymers in N,N-dimethylformamide. These micelles were pH-responsive as result of the pH-dependent ionization of the P2VP block. The impact of pH on the self-assembly of the binary mixture of diblocks-thus on the composition, shape, size and surface properties of the micelles-was Studied by a variety of experimental techniques, i.e., dynamic and static light scattering, transmission electron microscopy, Zeta potential, fluorescence spectroscopy and complement hemolytic 50 test. (C) 2008 Elsevier Inc. All rights reserved.

【 授权许可】

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