Peeling back the layers: Investigating the effects of polyelectrolyte layering on surface structure and stability of oil-in-water nanoemulsions

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:599

Article

Tran, Emma¹  Mapile, Ashley N.¹  Richmond, Geraldine L.¹ 

[1] Univ Oregon, Dept Chem & Biochem, Eugene, OR 97403 USA

关键词: Nanoemulsion stability;    Nanoemulsion interfacial properties;    Polymer;    surfactant adsorption behavior;    Poly(styrene sulfonate);    Polyethylenimine;    Layer-by-layer assembly;    Interfacial molecular conformational;    ordering;    Vibrational sum frequency scattering;    spectroscopy;   

DOI  :  10.1016/j.jcis.2021.04.115

来源: Elsevier

【 摘 要 】

Hypothesis: Layer-by-layer deposition of polyelectrolytes is a useful technique for modifying surface functionalities. For drug delivery systems, alternating layers of biopolymers coat nanoemulsions, which house and protect the cargo until the time and destination of delivery. Here, we investigate molecular factors contributing to the stability and interfacial properties of nanoemulsions prepared by a co adsorption of polymers poly(styrene sulfonate) and polyethylenimine (PEI), and surfactant dodecyltrimethylammonium bromide. We hypothesize the interplay between electrosteric and hydrophobic effects upon multi-polymer co-adsorption contributes to both macroscopic and molecular-level interfacial properties of nanoemulsions. Experiments: To probe interfacial layering properties, we use vibrational sum frequency scattering spectroscopy with f-potential measurements to determine the adsorptive behavior and molecular conformational arrangement of the polymer layers. Complementing these interfacial studies are dynamic light scattering experiments measuring the nanoemulsion size distribution and polydispersity index over a 30-day period. Findings: Our light scattering, f-potential, and spectroscopic results of the nanoemulsion surface show that the duration of droplet stability and the degree of molecular orientation of adsorbed polymers can be tuned by surfactant concentration, PEI concentration, and pH. These results illustrate how molecular surface properties of multi-polymer coated nanoemulsions contribute to synergistic effects and droplet stability, enabling advancements in applications surrounding biopharmaceuticals, cosmetics, and food sciences. (c) 2021 Elsevier Inc. All rights reserved.

【 授权许可】

Free