Using a selective cadmium-binding peplipid to create responsive liquid crystalline nanomaterials

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:449

Article

Liu, Qingtao^1,2  Wang, Jinfeng³  Dong, Yao-Da¹  Boyd, Ben J.^1,2 

[1] Monash Univ, Drug Delivery Disposit & Dynam, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia

[2] Monash Univ, Monash Inst Pharmaceut Sci, ARC Ctr Excellence Convergent Bionano Sci & Techn, Parkville, Vic 3052, Australia

[3] Deakin Univ, Australian Future Fibres Res & Innovat Ctr, Inst Frontier Mat, Geelong, Vic 3217, Australia

关键词: Lipid liquid crystalline;    Specificity;    Metal ion;    Phase transition;    Nanoparticle;    Peptide;   

DOI  :  10.1016/j.jcis.2014.11.063

来源: Elsevier

【 摘 要 】

A specific metal ion-responsive lipid liquid crystalline (LLC) dispersion system was fabricated, which can work in buffer solutions. The LLC matrix was prepared from phytantriol which spontaneously forms the reversed bicontinuous cubic phase in water, and a novel peptide lipid conjugate (peplipid) consists of a myristate alkyl chain for anchoring into the phytantriol-based cubic bilayer and a peptide sequence for capturing a specific metal ion. The peplipid in its unbound state, when added into the phytantriol-based cubic system induces a positive effect on the bilayer curvature, resulting in the formation of the lamellar phase (vesicles) and the dispersion was transparent in appearance. Upon binding of the cadmium ion, the peplipid induces a negative effect on the lipid bilayer curvature and consequently leading to the formation of cubic phase and opaque appearance. In contrast, other metal ions, including buffering salts, could not sufficiently trigger the phase transition due to weak interaction with the peplipid. The high selectivity of metal ion interaction and triggered phase transition provide potential applications, such as in colloidalmineral separation, triggered drug release and treatment of cadmium (II) pollution. (C) 2014 Elsevier Inc. All rights reserved.

【 授权许可】

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