Insights into the synthesis of layered double hydroxide (LDH) nanoparticles: Part 1. Optimization and controlled synthesis of chloride-intercalated LDH

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:459

Article

Sun, Xiaodi¹  Neuperger, Erica¹  Dey, Sandwip K.^1,2 

[1] Arizona State Univ, Ira A Fulton Sch Engn, Ctr Intervent Biomat, Sch Engn Matter Transport & Energy, Tempe, AZ 85281 USA

[2] Arizona State Univ, Ira A Fulton Sch Engn, Sch Elect Comp & Energy Engn, Tempe, AZ 85281 USA

关键词: Controlled synthesis;    Layered double hydroxide nanoparticles;    Design of experiments;    Coprecipitation;   

DOI  :  10.1016/j.jcis.2015.07.073

来源: Elsevier

【 摘 要 】

Layered double hydroxide (LDH) nanoparticles have excellent anion-intercalating property, and their potential as theranostic nanovectors is high. However, understanding of the control of the mean particle size (MPS) and achievement of monodispersed particle size distribution (PSD) remains elusive. Herein, with the aid of statistical design of experiments on a model system of C1(-)-intercalated (Zn, Al)-LDH, controlled synthesis of single crystalline nanoparticles using the coprecipitation method followed by hydrothermal treatment (HT) was achieved in three steps. First, a 2(4-1) design enabled the identification of influential parameters for MPS (i.e., salt concentration, molar ratio of carbonate to aluminum, solution addition rate, and interaction between salt concentration and stirring rate) and PSD (i.e., salt concentration and stirring rate), as well as the optimum coprecipitation conditions that result in a monodispersed PSD (i.e., low salt concentration and high stirring rate). Second, a preliminary explanation of the HT was suggested and the optimum HT conditions for obtaining ideal Gaussian PSD with chi-squared (chi(2)) < 3 were found to be 85 degrees C for 5 h. Third, using a central composite design, a quantitative MPS model, expressed in terms of the significant factors, was developed and experimentally verified to synthesize nearly monodispersed LDH nanoparticles with MPS similar to 200-500 nm. (C) 2015 Elsevier Inc. All rights reserved.

【 授权许可】

Free