MoO3-x nanodots with dual enzyme mimic activities as multifunctional modulators for amyloid assembly and neurotoxicity

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:539

Article

Han, Qiusen^1,2  Wang, Xinhuan¹  Liu, Xueliang¹  Zhang, Yufei¹  Cai, Shuangfei¹  Qi, Cui¹  Wang, Chen^1,2  Yang, Rong^1,2 

[1] Univ Chinese Acad Sci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Ctr Mat Sci & Optoelect Engn, CAS Ctr Excellence Nanosci,Natl Ctr Nanosci & Tec, Beijing 100190, Peoples R China

[2] Univ Chinese Acad Sci, Sino Danish Coll, Sino Danish Ctr Educ & Res, Beijing 100190, Peoples R China

关键词: MoO3-x nanodots;    Enzyme-mimic activity;    Amyloid;    Pulsed laser ablation;    Neurotoxicity;   

DOI  :  10.1016/j.jcis.2018.12.093

来源: Elsevier

【 摘 要 】

Development of effective inhibitors toward A beta aggregation and reactive oxygen species (ROS) scavengers are of crucial therapeutic implications for Alzheimer's disease (AD). Herein, a novel agent with dual enzyme mimic activities has been fabricated as a multifunctional A beta fibrillation modulator. MoO3-x nanodots were synthesized by pulsed laser ablation (PLA) method in MoS2 nanosheets solutions, which may act directly as numerous fine targets. MoO3-x nanodots showed a uniform and monodispersed morphology, and the tiny dots were around 3-5 nm with a narrow size distribution. Due to the efficient charge transition between Mo5+/Mo6+ on the dots surface, MoO3-x nanodots exhibited excellent catalase and SOD mimic activities, which were adopted to alleviate A beta-mediated oxidative stress. Moreover, MoO3-x nanodots can efficiently inhibit A beta aggregation and destabilize the preformed fibrils, and eventually protect neuronal cells from apoptosis induced by A beta. Taken together, MoO3-x nanodots with multifunctional roles can act as a potential therapeutic strategy for treatment of amyloid induced neurotoxicity. (C) 2019 Elsevier Inc. All rights reserved.

【 授权许可】

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