Polystyrene perturbs the structure, dynamics, and mechanical properties of DPPC membranes: An experimental and computational study

JOURNAL OF COLLOID AND INTERFACE SCIENCE

卷:605

Article

Bochicchio, Davide¹  Cantu, Laura²  Cadario, Maria Vittoria²  Palchetti, Leonardo²  Natali, Francesca³  Monticelli, Luca⁴  Rossi, Giulia¹  Del Favero, Elena² 

[1] Univ Genoa, Dept Phys, Via Dodecaneso 33, I-16146 Genoa, Italy

[2] Univ Milan, Dept Med Biotechnol & Translat Med, LITA Vle Flli Cervi 93, I-20090 Segrate, Italy

[3] Inst Laue Langevin, 71 Ave Martyrs,CS 20156, F-38042 Grenoble 9, France

[4] CNRS, IBCP, UMR 5086, 7 Passage Vercors, F-69007 Lyon, France

关键词: Model membrane;    Lipid bilayer;    Polystyrene;    X-ray scattering;    Differential Scanning Calorimetry (DSC);    Elastic Neutron Scattering (ENS);    Molecular dynamics (MD);    Nanoplastics;   

DOI  :  10.1016/j.jcis.2021.07.069

来源: Elsevier

【 摘 要 】

Synthetic plastic oligomers can interact with the cells of living organisms by different ways. They can be intentionally administered to the human body as part of nanosized biomedical devices. They can be inhaled by exposed workers, during the production of multicomponent, polymer-based nanocomposites. They can leak out of food packaging. Most importantly, they can result from the degradation of plastic waste, and enter the food chain. A physicochemical characterization of the effects of synthetic polymers on the structure and dynamics of cell components is still lacking. Here, we combine a wide spectrum of experimental techniques (calorimetry, x-ray, and neutron scattering) with atomistic Molecular Dynamics simulations to study the interactions between short chains of polystyrene (25 monomers) and model lipid membranes (DPPC, in both gel and fluid phase). We find that doping doses of polystyrene oligomers alter the thermal properties of DPPC, stabilizing the fluid lipid phase. They perturb the membrane structure and dynamics, in a concentration-dependent fashion. Eventually, they modify the mechanical properties of DPPC, reducing its bending modulus in the fluid phase. Our results call for a systematic, interdisciplinary assessment of the mechanisms of interaction of synthetic, everyday use polymers with cell membranes. CO 2021 Published by Elsevier Inc.

【 授权许可】

Free