Effect of preoperative radiotherapy on stage IB2 and IIA2 cervical cancer: A retrospective cohort study

INTERNATIONAL JOURNAL OF SURGERY

卷:30

Article

Zhang, Tongqing¹  Kong, Weimin¹  Li, Fengshuang¹  Song, Dan¹  Liu, Tingting¹  Han, Chao¹  Jiao, Simeng¹  Chen, Jiao¹ 

[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Gynecol Oncol, Qihelou Rd, Beijing 100006, Peoples R China

关键词: Cervical cancer;    Stage IB2, IIA2;    Preoperative radiotherapy;    Radical surgery;   

DOI  :  10.1016/j.ijsu.2016.04.001

来源: Elsevier

【 摘 要 】

Introduction: The aim of the retrospective study was to investigate the therapeutic efficiency of the preoperative intracavitary radiotherapy combined with radical surgery on postoperative complications and long-term survival in patients with stage IB2 and IIA2 cervical cancer (CC). Methods: From January 1995 to December 2012, a total of 171 patients with stage IB2 or IIA2 CC were recruited into the study. They were divided into two groups according to the treatment modality provided: preoperative radiotherapy followed by radical surgery (n = 80), and radical surgery alone (n = 91). The clinical curative effect, postoperative complications and the postoperative prognosis of patients were evaluated and compared in two groups. The tumor response and survival of patients in two groups were observed in follow-up study. Results: There were no significant differences in the incidence of postoperative complications, intraoperative blood loss and surgery duration (P > 0.05) between the two groups. Preoperative radiotherapy did not improve the postoperative prognosis yet. Though patients undergoing preoperative radiotherapy showed the similar 1-(92.50% vs. 84.62%), 3-(85.00% vs. 81.32%) and 5-year (80.00% vs. 74.72%) survival rates, the 3- and 5-year locoregional control rates of them were much higher than those undergoing surgery alone (P < 0.05). Conclusion: Preoperative radiotherapy combined with radical surgery could improve locoregional control rate and would not increase the risk of postoperative complications. It may be a feasible treatment mode for early stage CC carcinoma. (c) 2016 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.

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