Effect of green tea (Camellia sinensis) extract on healing process of surgical wounds in rat

INTERNATIONAL JOURNAL OF SURGERY

卷:11

Article

Asadi, Sayyed Yazdan¹  Parsaei, Pouya²  Karimi, Mehrdad³  Ezzati, Sareh¹  Zamiri, Alaleh⁴  Mohammadizadeh, Fereshteh⁵  Rafieian-kopaei, Mahmoud⁶ 

[1] Shahrekord Univ Med Sci, Fac Med, Med Plants Res Ctr, Shahrekord, Iran

[2] Islamic Azad Univ, Young Researchers Club, Shahrekord Branch, Shahrekord, Iran

[3] Shahrekord Univ Med Sci, Dept Surg, Shahrekord, Iran

[4] Univ Tehran Med Sci, Fac Med, Tehran, Iran

[5] Isfahan Univ Med Sci, Fac Med, Dept Pathol, Esfahan, Iran

[6] Shahrekord Univ Med Sci, Med Plants Res Ctr, Shahrekord, Iran

关键词: Green tea;    Camellia sinensis;    Healing process;    Surgical wound;    Rat;   

DOI  :  10.1016/j.ijsu.2013.02.014

来源: Elsevier

【 摘 要 】

Green tea (Camellia sinensis) has anti-oxidant and anti-inflammatory properties and may enhance wound healing process. The present study, therefore, was aimed to examine the effect of green tea ethanolic extract on wound healing process. For this experimental study, 36 healthy male Wistar rats were randomly designated to three groups of A, B, and C which, respectively treated with, Vaseline + 0.6% green tea extract, Vaseline and normal saline for 21 days. Wounds' length and area were measured by caliper every other day and specimens were taken at 3rd, 12th, and 21st day for microscopical examinations. Data were analyzed by SPSS 16 using survival analysis (Breslow test), repeated measured ANOVA, one-way ANOVA and Mann-Whitney. P < 0.05 was considered as statistically significant. The mean healing duration of surgical wounds in groups A and B was 14.66 and 20.66 (P = 0.018), respectively. Decrease in healing duration in the group A was significantly higher within the first two weeks compared with control groups (P 0.05). Microscopic examinations also indicated a significant difference in wound healing process between groups A and C throughout the whole study duration as well as groups A and B during the 3rd week of the study (P < 0.05). Green tea extract could help wound healing process, probably effective on surgical wounds healing. (C) 2013 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

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