The early diagnostic value of C-reactive protein for anastomotic leakage post radical gastrectomy for esophagogastric junction carcinoma: A retrospective study of 97 patients

INTERNATIONAL JOURNAL OF SURGERY

卷:27

Article

Ji, Litong¹  Wang, Tie²  Tian, Lining³  Gao, Meizhuo¹ 

[1] Harbin Med Univ, Forth Affiliated Hosp, Dept Gen Surg, 37 Yiyuan St, Harbin 150001, Helongjian, Peoples R China

[2] Harbin Med Univ, Canc Hosp, Dept Gastrointestinal Surg, Harbin 150001, Helongjian, Peoples R China

[3] Harbin Med Univ, Affiliated Hosp 1, Dept Med Educ, Harbin 150001, Helongjian, Peoples R China

关键词: C-reactive protein;    Esophagogastric junction carcinoma;    Surgery;    Anastomotic leakage;   

DOI  :  10.1016/j.ijsu.2016.02.021

来源: Elsevier

【 摘 要 】

Background/Aims: The incidence of esophagogastric junction (EGJ) carcinoma has increased worldwide. The only curable strategy for EGJ carcinoma is surgery, whereas anastomotic leakage is the major complication after operations. We aimed to test whether the serum levels of C-reactive protein have the diagnostic value for anastomotic leakage after surgery for EGJ carcinoma. Methods: In this study, we analyzed the values of CRP before and 5 continuous days after surgery in 97 EGJ carcinoma patients who received surgery as the initial treatment. The levels of CRP in the groups of EGJ patients with or without anastomotic leakage were compared. Results: The CRP levels of patients with anastomotic leakage elevated faster and remained higher compared patients without anastomotic leakage. The CRP value at Day 2 after radical surgery for EGJ carcinoma patients has the early diagnostic value for anastomotic leakage. The cut-off value of CRP for anastomotic leakage at Day 2 is 177 mg/l with the sensitivity of 0.9 and specificity of 0.95 (P < 0.0001). Conclusion: Surgical EGJ carcinoma patients with elevated CRP at Day 2 after surgery should be excluded the possibility of anastomotic leakage. (C) 2016 IJS Publishing Group Limited. Published by Elsevier Ltd. All rights reserved.

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