Gallbladder intestinal metaplasia in Pakistani patients with gallstones

INTERNATIONAL JOURNAL OF SURGERY

卷:9

Article

Khan, Muhammad Rizwan²  Raza, Syed Ahsan^1,2  Ahmad, Zubair³  Naeem, Sana²  Pervez, Shahid³  Siddiqui, Anwar Ali⁴  Ahmed, Mushtaq⁵  Azami, Rizwan² 

[1] Univ Montreal, Dept Med Sociale & Prevent, Montreal, PQ H2W 1V1, Canada

[2] Aga Khan Univ, Dept Surg, Karachi, Pakistan

[3] Aga Khan Univ, Dept Pathol & Microbiol, Karachi, Pakistan

[4] Aga Khan Univ, Dept Biol & Biomed Sci, Karachi, Pakistan

[5] Aga Khan Univ, Nairobi, Kenya

关键词: Cancer;    Gallbladder;    Metaplasia;    Gallstones;   

DOI  :  10.1016/j.ijsu.2011.07.001

来源: Elsevier

【 摘 要 】

The gallbladder specimens of patients who underwent cholecystectomy for symptomatic gallstones between 2003 and 2005 were evaluated for the presence of Intestinal Metaplasia. (IM) and its risk factors. IM was positive in 39% of 293 patients tested, and in the comparative analysis of 114 metaplasia positive versus 179 negative patients, a high risk was found in patients who were 60 years or older [ adjusted odds ratio (aOR) = 3.0, 95% confidence interval (CI): 1.5, 6.2]. Other factors with aOR greater than 1 were moderate to excessive use of chilies (1.8) and ethnic origin of North India (1.7). Screening method has yet to be devised for early detection of gallbladder cancer by identifying metaplastic lesions early in life. We believe that large geographic variation and lifestyle environmental factors associated with the development of gallbladder metaplasia and cancer mortality are concealed in our study that needs to be further explored. (C) 2011 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free