Possible detrimental effects of neurosurgical irrigation fluids on neural tissue: An evidence based analysis of various irrigants used in contemporary neurosurgical practice

INTERNATIONAL JOURNAL OF SURGERY

卷:8

Review

Kazim, Syed Faraz¹  Enam, Syed Ather¹  Shamim, Muhammad Shahzad¹ 

[1] Aga Khan Univ Hosp, Dept Surg, Neurosurg Sect, Karachi 74800, Pakistan

关键词: Neurosurgical irrigation fluids;    Harmful effects;    Central nervous system cells;    Physiological saline;    Lactated Ringer's solution;    Artificial cerebrospinal fluid;   

DOI  :  10.1016/j.ijsu.2010.07.292

来源: Elsevier

【 摘 要 】

Physiological saline and other solutions used as irrigation fluids during neurosurgical procedures have long been debated to cause adverse effects on neural tissue. Laboratory based research over the past fifty years has described the possible harm caused to central nervous system cells by normal saline, and has advocated the use of safer alternatives such as lactated Ringer's solution and artificial cerebrospinal fluid. However, there is a dearth of corresponding clinical studies to support this standpoint. Worldwide, normal saline remains the most widely used neurosurgical irrigation fluid. We have attempted to document the preference of practicing neurosurgeons worldwide regarding the irrigation fluids via an electronic mail survey, and have analyzed the available evidence on the relative safety of various irrigation fluids. We recommend the use of lactated Ringer's solution and artificial cerebrospinal fluid as neurosurgical irrigants, especially during neuroendoscopy and longer procedures requiring application of copious amount of irrigation fluid. (C) 2010 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

【 授权许可】

Free