Bile acid transporters and regulatory nuclear receptors in the liver and beyond

JOURNAL OF HEPATOLOGY

卷:58

Review

Halilbasic, Emina¹  Claudel, Thierry¹  Trauner, Michael¹ 

[1] Med Univ Vienna, Dept Internal Med 3, Div Gastroenterol & Hepatol, Hans Popper Lab Mol Hepatol, A-1090 Vienna, Austria

关键词: Bile acids;    Cholestasis;    Fatty liver disease;    Gallstones;    Liver regeneration;    Liver cancer;   

DOI  :  10.1016/j.jhep.2012.08.002

来源: Elsevier

【 摘 要 】

Bile acid (BA) transporters are critical for maintenance of the enterhepatic BA circulation where BAs exert their multiple physiological functions including stimulation of bile flow, intestinal absorption of lipophilic nutrients, solubilization and excretion of cholesterol, as well as antimicrobial and metabolic effects. Tight regulation of BA transporters via nuclear receptors is necessary to maintain proper BA homeostasis. Hereditary and acquired defects of BA transporters are involved in the pathogenesis of several hepatobiliary disorders including cholestasis, gallstones, fatty liver disease and liver cancer, but also play a role in intestinal and metabolic disorders beyond the liver. Thus, pharmacological modification of BA transporters and their regulatory nuclear receptors opens novel treatment strategies for a wide range of disorders. (C) 2012 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free