The Chinese Society of Hepatology position statement on the redefinition of fatty liver disease

JOURNAL OF HEPATOLOGY

卷:75

Article

Nan, Yuemin¹  An, Jihong²  Bao, Jianfeng³  Chen, Hongsong⁴  Chen, Yu⁵  Ding, Huiguo⁵  Dou, Xiaoguang⁶  Duan, Zhongping⁵  Fan, Jiangao⁷  Gao, Yanhang⁸  Han, Tao⁹  Han, Ying¹⁰  Hu, Peng¹¹  Huang, Yan¹²  Huang, Yuan¹³  Jia, Jidong¹⁴  Jiang, Jiaji¹⁵  Jiang, Ying'an¹⁶  Li, Jie¹⁷  Li, Jun¹⁸  Li, Rongkuan¹⁹  Li, Shuchen²⁰  Li, Wengang²¹  Li, Yufang²²  Lin, Shumei²³  Liu, Jingfeng²⁴  Liu, Shourong²⁵  Lu, Lungen²⁶  Lu, Qinghua²⁷  Luo, Xinhua²⁸  Ma, Xiong²⁹  Rao, Huiying⁴  Ren, Hong³⁰  Ren, Wanhua³¹  Shang, Jia^32,33  Shi, Li³⁴  Su, Minghua³⁵  Wang, Bingyuan³⁶  Wang, Rongqi¹  Wei, Lai¹³  Wen, Zhili³⁷  Wu, Biao³⁸  Wu, Jing³⁹  Xin, Shaojie⁴⁰  Xing, Huichun⁴¹  Xu, Jinghang⁴²  Yan, Ming⁴³  Yang, Jiming⁴⁴  Yang, Jinhui⁴⁵  Yang, Li⁴⁶  Yang, Yongfeng⁴⁷  Yu, Yanyan⁴⁵  Zhang, Liaoyun⁴⁸  Zhang, Lingyi⁴⁹  Zhang, Xinxin⁵⁰  Zhang, Yuguo³⁸  Zhang, Yuexin⁵¹  Zhao, Jingmin⁵²  Zhao, Shousong⁵³  Zheng, Huanwei⁵⁴  Zhou, Yongjian⁵⁵  Zhou, Yongning⁵⁶  Zhuang, Hui^17,57  Zuo, Weize⁵⁸  Xu, Xiaoyuan⁴⁵  Qiao, Liang⁵⁹ 

[1] Hebei Med Univ, Hosp 3, Dept Tradit & Western Med Hepatol, Shijiazhuang 050051, Hebei, Peoples R China

[2] Inner Mongolia Autonomous Reg Peoples Hosp, Dept Infect Dis, Hohhot 010017, Inner Mongolia, Peoples R China

[3] Hangzhou Xixi Hosp, Dept Hepatol, Hangzhou 310023, Peoples R China

[4] Peking Univ Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China

[5] Capital Med Univ, Beijing Youan Hosp, Beijing 100069, Peoples R China

[6] China Med Univ, Shengjing Hosp, Dept Infect Dis, Shenyang 110022, Peoples R China

[7] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Gastroenterol, Shanghai 200092, Peoples R China

[8] First Hosp Jilin Univ, Dept Hepatol, Changchun 130021, Peoples R China

[9] Tianjin Third Cent Hosp, Dept Hepatol & Gastroenterol, Tianjin 300170, Peoples R China

[10] Air Force Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Xian 710032, Peoples R China

[11] Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Chongqing 400016, Peoples R China

[12] Cent South Univ, Xiangya Hosp, Dept Infect Dis, Changsha 410008, Peoples R China

[13] Tsinghua Univ, Affiliated Beijing Tsinghua Changgung Hosp, Beijing 102218, Peoples R China

[14] Capital Med Univ, Beijing Friendship Hosp, Liver Res Ctr, Beijing 100050, Peoples R China

[15] Fujian Med Univ, Affiliated Hosp 1, Liver Dis Res Ctr, Fuzhou 350001, Peoples R China

[16] Wuhan Univ, Dept Infect Dis, Renmin Hosp, Wuhan 430060, Peoples R China

[17] Peking Univ Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China

[18] Zhejiang Univ, Affiliated Hosp 1, Sch Med, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Peoples R China

[19] Dalian Med Univ, Dept Infect Dis, Hosp 2, Dalian 116027, Peoples R China

[20] Harbin Med Univ, Affiliated Hosp 2, Dept Infect Dis, Harbin 150081, Peoples R China

[21] Chinese Peoples Liberat Army Gen Hosp, Radiat Oncol Ctr, Med Ctr 5, Beijing 100039, Peoples R China

[22] Ningxia Med Univ, Dept Infect Dis, Gen Hosp, Yinchuan 750004, Ningxia, Peoples R China

[23] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Infect Dis, Xian 710061, Peoples R China

[24] Fujian Med Univ, Mengchao Hepatobiliary Hosp, Fuzhou 350025, Peoples R China

[25] Hangzhou Xixi Hosp, Dept Infect Dis, Hangzhou 310023, Peoples R China

[26] Shanghai Jiao Tong Univ, Sch Med, Dept Gastroenterol, Shanghai Gen Hosp, Shanghai 200080, Peoples R China

[27] Fourth Peoples Hosp Qinghai Prov, Dept Liver Dis, Xining 810001, Peoples R China

[28] Guizhou Prov Peoples Hosp, Dept Infect Dis, Guiyang 550002, Peoples R China

[29] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai Inst Digest Dis,Dept Gastroenterol, Shanghai 200001, Peoples R China

[30] Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400016, Peoples R China

[31] Shandong Univ, Shandong Prov Hosp, Dept Infect Dis, Jinan 250021, Peoples R China

[32] Zhengzhou Univ Peoples Hosp, Henan Prov Peoples Hosp, Dept Infect Dis, Zhengzhou 450003, Peoples R China

[33] Henan Univ Peoples Hosp, Zhengzhou 450003, Peoples R China

[34] Peoples Hosp Tibet Autonomous Reg, Dept Infect Dis, Lhasa 850000, Peoples R China

[35] Guangxi Med Univ, Affiliated Hosp 1, Dept Infect Dis, Nanning 530021, Peoples R China

[36] China Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Shenyang 110001, Peoples R China

[37] Nanchang Univ, Affiliated Hosp 2, Dept Gastroenterol, Nanchang 330008, Jiangxi, Peoples R China

[38] Hainan Gen Hosp, Dept Infect Dis, Haikou 570311, Hainan, Peoples R China

[39] Capital Med Univ, Beijing Friendship Hosp, Dept Gastroenterol, Beijing 100050, Peoples R China

[40] Chinese Peoples Liberat Army Gen Hosp, Liver Failure Treatment & Res Ctr, Med Ctr 5, Beijing 100039, Peoples R China

[41] Capital Med Univ, Beijing Ditan Hosp, Ctr Liver Dis Div 3, Beijing 100015, Peoples R China

[42] Peking Univ First Hosp, Dept Infect Dis, Beijing 100034, Peoples R China

[43] Shandong Univ, Qilu Hosp, Dept Hepatol & Gastroenterol, Jinan 250012, Peoples R China

[44] Tianjin Second Peoples Hosp, Tianjin 300192, Peoples R China

[45] Kunming Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Kunming 650000, Yunnan, Peoples R China

[46] Sichuan Univ, West China Hosp, Chengdu 610041, Peoples R China

[47] Nanjing Univ Chinese Med, Hosp Nanjing 2, Nanjing 210003, Peoples R China

[48] Shanxi Med Univ, Dept Infect Dis, Hosp 1, Taiyuan 030001, Peoples R China

[49] Lanzhou Univ Second Hosp, Dept Hepatol, Lanzhou 730030, Peoples R China

[50] Shanghai Jiao Tong Univ, Ruijin Hosp, Sch Med, Dept Infect Dis, Shanghai 200025, Peoples R China

[51] Xinjiang Med Univ, Affiliated Hosp 1, Ctr Infect Dis, Urumqi 830000, Peoples R China

[52] Peoples Liberat Army Gen Hosp, Beijing 302 Hosp, Ctr Pathol Diag & Res, Med Ctr 5, Beijing 100039, Peoples R China

[53] Bengbu Med Coll, Affiliated Hosp 1, Dept Infect Dis, Bengbu 233000, Peoples R China

[54] Fifth Hosp Shijiazhuang, Liver Res Ctr, Shijiazhuang 050021, Hebei, Peoples R China

[55] Guangzhou First Peoples Hosp, Dept Gastroenterol, Guangzhou 510181, Peoples R China

[56] Lanzhou Univ, Dept Gastroenterol, Hosp 1, Lanzhou 730000, Peoples R China

[57] Peking Univ Hlth Sci Ctr, Ctr Infect Dis, Beijing 100191, Peoples R China

[58] Shihezi Univ, Affiliated Hosp 1, Sch Med, Dept Infect Dis, Urumqi 832000, Xinjiang Uygur, Peoples R China

[59] Univ Sydney, Westmead Hosp, Storr Liver Ctr, Westmead Inst Med Res, Westmead, NSW 2145, Australia

关键词: MAFLD;    NAFLD;    voting;    Consensus;    China;   

DOI  :  10.1016/j.jhep.2021.05.003

来源: Elsevier

【 摘 要 】

Fatty liver disease associated with metabolic dysfunction is of increasing concern in mainland China, the world's most populous country. The incidence of fatty liver disease is highest in China, surpassing the incidence in European countries and the USA. An international consensus panel recently published an influential report recommending a novel definition of fatty liver disease associated with metabolic dysfunction. This recommendation includes a switch in name from non-alcoholic fatty liver disease (NAFLD) to metabolic (dysfunction)-associated fatty liver disease (MAFLD) and adoption of a set of positive criteria for disease diagnosis that are independent of alcohol intake or other liver diseases. Given the unique importance of this proposal, the Chinese Society of Hepatology (CSH) invited leading hepatologists and gastroenterologists representing their respective provinces and cities to reach consensus on alternative definitions for fatty liver disease from a national perspective. The CSH endorses the proposed change from NAFLD to MAFLD (supported by 95.45% of participants). We expect that the new definition will result in substantial improvements in health care for patients and advance disease awareness, public health policy, and political, scientific and funding outcomes for MAFLD in China. (C) 2021 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

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