Ursodeoxycholic acid in pregnancy?

JOURNAL OF HEPATOLOGY

卷:71

Review

de Vries, Elsemieke^1,2  Beuers, Ulrich^1,2 

[1] Univ Amsterdam, Med Ctr, Locat AMC, Dept Gastroenterol & Hepatol, Amsterdam, Netherlands

[2] Univ Amsterdam, Med Ctr, Locat AMC, Tytgat Inst Liver & Intestinal Res, Amsterdam, Netherlands

关键词: Lactation;    Primary biliary cholangitis;    PBC;    Primary sclerosing cholangitis;    PSC;    Stillbirth;    UDCA;   

DOI  :  10.1016/j.jhep.2019.08.020

来源: Elsevier

【 摘 要 】

The case of a 34-year-old woman with primary biliary cholangitis (PBC) before, during and after pregnancy is described. The use of ursodeoxycholic acid (UDCA) during and after pregnancy is discussed. UDCA has not been approved by the drug regulatory authorities as a pregnancy-safe drug; therefore, the reluctance of clinicians to prescribe UDCA during pregnancy is understandable. This Grand Round aims to provide a detailed analysis of the current evidence, safety data and clinical experience with UDCA (and alternative drugs) during pregnancy and lactation. Based on this analysis, advice for clinicians regarding the use of UDCA during pregnancy and lactation is given. (C) 2019 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free