Determinants of mortality in patients with cirrhosis and uncontrolled variceal bleeding

JOURNAL OF HEPATOLOGY

卷:74

Article

Kumar, Rahul^1,2,3  Kerbert, Annarein J. C.¹  Sheikh, M. Faisal¹  Roth, Noam⁴  Calvao, Joana A. F.^1,7  Mesquita, Monica D.^1,7  Barreira, Ana I.^1,7  Gurm, Haqeeqat S.¹  Ramsahye, Komal¹  Mookerjee, Rajeshwar P.¹  Yu, Dominic⁵  Davies, Neil H.⁵  Mehta, Gautam¹  Agarwal, Banwari^1,4  Patch, David⁶  Jalan, Rajiv¹ 

[1] UCL Med Sch, UCL Inst Liver & Digest Hlth, Liver Failure Grp, Royal Free Campus, London, England

[2] Changi Gen Hosp, Dept Gastroenterol & Hepatol, Singapore, Singapore

[3] Duke NUS Acad Med Ctr, CGH Campus, Singapore, Singapore

[4] Royal Free Hosp London NHS Fdn Trust, Intens Care Unit, London, England

[5] Royal Free Hosp London NHS Fdn Trust, Dept Radiol, London, England

[6] Royal Free London NHS Trust, Royal Free Sheila Sherlock Liver Ctr, London, England

[7] Ctr Hosp Tras Os Montes & Alto Douro, EPE, Vila Real, Portugal

关键词: Acute variceal bleeding;    Esophageal varices;    Acute-on-chronic liver failure;    ACLF;    Transjugular intrahepatic portosystemic shunt;    TIPS;   

DOI  :  10.1016/j.jhep.2020.06.010

来源: Elsevier

【 摘 要 】

Background & Aims: Failure to control oesophago-gastric variceal bleeding (OGVB) and acute-on-chronic liver failure (ACLF) are both important prognostic factors in cirrhosis. The aims of this study were to determine whether ACLF and its severity define the risk of death in OGVB and whether insertion of rescue transjugular intrahepatic shunt (TIPS) improves survival in patients with failure to control OGVB and ACLF. Methods: Data on 174 consecutive eligible patients, with failure to control OGVB between 2005 and 2015, were collected from a prospectively maintained intensive care unit registry. Rescue TIPS was defined as technically successful TIPS within 72 hours of presentation with failure to control OGVB. Cox-proportional hazards regression analyses were applied to explore the impact of ACLF and TIPS on survival in patients with failure to control OGVB. Results: Patients with ACLF (n = 119) were significantly older, had organ failures and higher white cell count than patients with acute decompensation (AD, n = 55). Mortality at 42-days and 1-year was significantly higher in patients with ACLF (47.9% and 61.3%) than in those with AD (9.1% and 12.7%, p <0.001), whereas there was no difference in the number of endoscopies and transfusion requirements between these groups. TIPS was inserted in 78 patients (AD 21 [38.2%]; ACLF 57 [47.8%]; p = 0.41). In ACLF, rescue TIPS insertion was an independent favourable prognostic factor for 42-day mortality. In contrast, rescue TIPS did not impact on the outcome of patients with AD. Conclusions: This study shows that in patients with failure to control OGVB, the presence and severity of ACLF determines the risk of 42-day and 1-year mortality. Rescue TIPS is associated with improved survival in patients with ACLF. Lay summary: Variceal bleeding that is not controlled by initial endoscopy is associated with high risk of death. The results of this study showed that in the occurrence of failure of the liver and other organs defines the risk of death. In these patients, insertion of a shunt inside the liver to drain the portal vein improves survival. (C) 2020 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

【 授权许可】

Free