Clinical outcomes of donation after circulatory death liver transplantation in primary sclerosing cholangitis

JOURNAL OF HEPATOLOGY

卷:67

Article

Trivedi, Palak J.^1,2  Scalera, Irene²  Slaney, Emma²  Laing, Richard W.^1,2  Gunson, Bridget^1,2  Hirschfield, Gideon M.^1,2  Schlegel, Andrea^2,3  Ferguson, James^1,2  Muiesan, Paolo^1,2,4 

[1] Univ Birmingham, Inst Immunol & Immunotherapy, Birmingham Liver Biomed Res Ctr BRC, NIHR, Birmingham, W Midlands, England

[2] Queen Elizabeth Hosp Birmingham, Univ Hosp Birmingham NHS Fdn Trust, Liver Unit, Birmingham, W Midlands, England

[3] Univ Hosp Zurich, Dept Surg & Transplantat, Zurich, Switzerland

[4] Birmingham Childrens Hosp NHS Fdn Trust, Dept Liver Surg, Birmingham, W Midlands, England

关键词: Primary sclerosing cholangitis;    Liver transplantation;    Ulcerative colitis;    Ischaemic-type biliary lesion;    Non-anastomotic biliary stricture;    Hepatic artery thrombosis;    Non-heart beating donor;    Risk stratification;   

DOI  :  10.1016/j.jhep.2017.06.027

来源: Elsevier

【 摘 要 】

Background & Aim: Primary sclerosing cholangitis (PSC) is a progressive fibro-inflammatory cholangiopathy for which liver transplantation is the only life-extending intervention. These patients may benefit from accepting liver donation after circulatory death (DCD), however their subsequent outcome is unknown. The aim of this study was to determine the clinical impact of using DCD liver grafts in patients specifically undergoing transplantation for PSC. Methods: Clinical outcomes were prospectively evaluated in PSC patients undergoing transplantation from 2006 to 2016 stratified by donor type (DCD, n = 35 vs. donation after brainstem death [DBD], n = 108). Results: In liver transplantation for PSC; operating time, days requiring critical care support, total ventilator days, incidence of acute kidney injury, need for renal replacement therapy (RRT) or total days requiring RRT were not significantly different between DCD vs. DBD recipients. Although the incidence of ischaemic-type biliary lesions was greater in the DCD group (incidence rate [IR]: 4.4 vs. 0 cases/100-patient-years; p < 0.001) there was no increased risk of post-transplant biliary strictures overall (hazard ratio [HR]: 1.20, 0.58-2.46; p = 0.624), or in sub-analysis specific to anastomotic strictures or recurrent PSC, between donor types. Graft loss and mortality rates were not significantly different following transplantation with DCD vs. DBD livers (IR: 3.6 vs. 3.1 cases/100-patient-years, p = 0.34; and 3.9 vs. 4.7, p = 0.6; respectively). DCD liver transplantation in PSC did not impart a heightened risk of graft loss (HR: 1.69, 0.58-4.95, p = 0.341) or patient mortality (0.75, 0.25-2.21, p = 0.598). Conclusion: Transplantation with DCD (vs. DBD) livers in PSC patients does not impact graft loss or patient survival. In an era of organ shortage, DCD grafts represent a viable therapeutic option for liver transplantation in PSC patients. (C) 2017 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

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